A postdoctoral position is available in the group of Prof. Bernd Bodenmiller at the Institute of Molecular Life Sciences at the University of Zurich (www.bodenmillerlab.org). The successful candidate will study the cell composition and heterogeneity of solid tumors through all stages of tumor development by mass cytometry. Mass cytometry is a recent single cell analysis technology that allows measurement of up to 100 proteins, phosphorylation sites and other markers simultaneously and thus is uniquely suited to describe cell phenotypes and signaling network state. For this project also CyTOF imaging mass cytometry (see Nature Methods, 2014) to visualize dozens of biomarkers simultaneously with subcellular resolution on tissues will be exploited. Based on the generated single cell data, mathematical approaches will be used to model tumor development and heterogeneity. Hypotheses on how to modulate tumor development will be inferred and validated by targeted molecular biology approaches.
a highly motivated Ph.D. or M.D.-Ph.D. with a passion for science who would like to work in an collaborative multidisciplinary research field that combines systems biology, biotechnology, biomedicine, bioinformatics, molecular biology and analytical sciences (For more information see www.bodenmillerlab.org).
Ideally you have
- a strong background in the analysis of tumor heterogeneity in tumor samples,
- a strong background or at least familiarity with data analysis/bioinformatics approaches,
- optionally experience with mass cytometry,
- willingness to collaborate with researchers of other areas (e.g., bioinformatics), and
- a track record of first author publications in peer-reviewed journals.
sending by email a cover letter (including an explanation of your motivation), CV and at least two references to Prof. B. Bodenmiller (firstname.lastname@example.org). This position will be available in March 2015 and applications will be considered until the position is filled.
Prof. Bernd Bodenmiller, Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland….