Postdoctoral positions are available in the laboratory of Asst Prof Meng How Tan at the Nanyang Technological University (NTU) in Singapore. Our laboratory is broadly interested in systems and synthetic biology and adopts interdisciplinary approaches (both wet lab and dry lab) to tackle important biomedical and biotechnological questions. Specifically, we focus on the following problem: How are cell fate decisions made in the presence of different environmental signals? We investigate the problem in both microorganisms and human cells.
Despite their simplicity, microbes can exist in different cell states. They may be free-swimming in the environment in search of nutrients or anchored to a surface to form a biofilm. Some microbes can even form hardy spores. How do intracellular networks, such as the cell cycle control system, integrate information from different environmental conditions to enable a microbial cell to exist in a particular state or to switch from one state to another? This research has important implications for infectious diseases and biotechnology, such as development of new antibiotics, new biosensing and bioremediation strategies, or new microbial fuel cells.
Human pluripotent stem cells have the ability to differentiate into all cell types in the body and hence hold tremendous potential for regenerative medicine. However, despite years of intense study, the regulatory networks that control the differentiation of these stem cells into various ectodermal, mesodermal, or endodermal lineages are still poorly understood. We are developing and applying new cutting edge technologies to dissect the regulatory networks controlling cellular differentiation. We are interested not only in epigenetic and transcriptional networks but are also interested in post-transcriptional mechanisms, such as RNA editing. Furthermore, we study how a terminally differentiated somatic cell can lose its identity in devastating human diseases, such as cancer, and revert to a more primitive state.
We are seeking highly motivated and independent postdoctoral fellows with proven academic track records and interest in interdisciplinary research. We will like to hire both experimental postdocs with experience in microbiology, time-lapse microscopy, developmental biology, RNA biology, cancer, genome engineering (such as CRISPR-Cas9) or genomics as well as computational postdocs with experience in bioinformatics, analysis of deep sequencing datasets, or modeling and simulation of biological systems.
Interested candidates should submit a detailed CV to Asst Prof Meng How Tan (mh.tan at ntu.edu.sg) and a statement of why you are interested in joining our lab. We regret that only shortlisted candidates will be notified. …http://www.mhtanlab.com