Highly motivated candidates with a passion for science are encouraged to apply for a postdoctoral position at the University of Toronto and the University Health Network to study the role of noncoding RNAs in regulating blood vessel inflammation. The lab of Dr. Jason Fish utilizes a cross-disciplinary approach to investigate the molecular mechanisms regulating endothelial cell biology in both health and disease. We are particularly interested in how noncoding RNAs control gene expression at both the transcriptional and post-transcriptional levels. We utilize cutting edge molecular and cellular approaches in both in vitro and in vivo (mouse and zebrafish) models of vascular biology/disease, and have ready access to human clinical samples. Current projects include: determining how circulating microvesicles/microRNAs regulate vascular inflammation and disease, and defining the molecular mechanisms whereby long noncoding RNAs regulate endothelial activation.
Recent papers: Cheng et al, Frontiers in Genetics, 2014; Delgado-Olguin et al, Development, 2014; Wythe et al, Developmental Cell, 2013; Cheng et al, EMBO Molecular Medicine, 2013; Dang et al, Arteriosclerosis Thrombosis and Vascular Biology, 2013; Fish and Cybulsky, Journal of Clinical Investigation, 2012; Fish et al, Development, 2011; Fish et al, Journal of Biological Chemistry, 2010; Fish et al, Science Signaling, 2009; Fish et al, Developmental Cell, 2008
The ideal candidate will have recently obtained (within the past 3 years) a PhD degree in biomedical sciences. They should have a proven track record of research productivity, including publication(s) in peer-reviewed journals, as well as superb oral and written communication skills. A strong background in cellular and molecular biology is essential. Experience with in vivo models (i.e. mouse or zebrafish) would be beneficial.
Applicants should send a cover letter describing their interest in the lab and how they envision themselves integrating into the lab, a CV, and the names and e-mail contact information of 3 references to: