莱里达大学染色体研究博士后职位

日期:2015-01-04
We are looking for a highly motivated Postdoctoral Researcher to join our team in the laboratory of Dr. Jordi Torres-Rosell at the IRBLLEIDA Biomedical Research Institute – University of Lleida. Our research focuses on the regulation of SMC complexes during genome replication and segregation.

Molecular mechanisms of SUMO-dependent sister chromatid cohesion

We are looking for a highly motivated Postdoctoral Researcher to join our team in the laboratory of Dr. Jordi Torres-Rosell at the IRBLLEIDA Biomedical Research Institute – University of Lleida. Our research focuses on the regulation of SMC complexes during genome replication and segregation.

The following position is available initially for 18 months starting in spring 2015. The postdoctoral positions will be funded by an Explora Ciencia MINECO grant, but the candidate is also encouraged to apply for independent postdoctoral funding.

Research Summary:

One of the most important complexes for chromosome architecture and dynamics is cohesin, a ring-shaped complex that topologically links sister chromatids. Its ability to entrap chromatin fibers inside its ring structure is not only required for chromosome segregation, but also for the repair of DNA damage and most probably for the regulation of gene expression during development. Not surprisingly, it is classified as a cancer gene, and its mutation can cause developmental disorders known as cohesinopathies. Despite its wide relevance in chromosome biology, we still do not understand how cohesin rings join chromatin fibers. The main model proposed so far is one based on the threading of replication forks through cohesin rings, a mechanism that would passively link replicated sisters. However, this mechanism does not account for situations where cohesion can be established in the absence of replication forks, such as in response to DNA damage. Moreover, cohesin might also regulate gene expression in non-replicating cells, most probably through entrapment of chromatin fibers to stabilize loops.

We plan to use cellular and biochemical approaches to understand how chromatin fibers are selected for entrapment inside cohesin rings. The successful candidate will be in charge to test a new and simple yet radical model for cohesion establishment. Prior experience with molecular biology, microscopy and yeast genetics is desirable. Experience in cell cycle and chromosome biology would be advantageous.

Principal duties:

- Carry out laboratory-based research to the highest standard.
- Contribute intellectually and strategically to the development of the project.
- Present information and data to members of the lab and participate in discussions.
- Coordinate and communicate with collaborators and other teams.
- Supervision and training of students in techniques and use of equipment.
- Writing up grants and research work for publication

Desired skills and experience

- To hold a PhD at the time of application.
- Experience in the fields of cell cycle and yeast as a model organism.
- To have an good publication track record with a strong background in cell and molecular biology.
- Strong English language skills.

For more information visit:

http://web.udl.es/usuaris/l4372283/

微信扫一扫分享资讯

相关阅读
德国基尔大学骨转移研究博士后职位
杜塞尔多夫大学毒理学研究博士后职位
荷兰AMR临床遗传学研究博士后职位
谢菲尔德大学分子生物学研究博士后职位
威廉邓恩病理学院人类基因表达调控研究博士后职位
隆德大学干细胞调控研究博士后职位
哪四类求职者最让人反感?

不要做让HR管理者反感的人,要做一个让HR管理者欣赏的人。如果你有以上的坏毛病,一定要改正,因为这些坏毛病会阻碍到你求职,影响到你以后在职场上的发展。

合肥市口腔医院急聘口腔专业博士、硕士

安徽省内唯一一家三级口腔专科医院,创建于1956年,历经六十年的风雨兼程,已发展成为集医、教、研、防为一体的现代化口腔专科医院,并形成了“一院、两区、三部”的格局,现在面向全国急招口腔方面专业人才,欢迎您的投递!

总务科主任招聘 男外科助理招聘 美容医助招聘 检验经理招聘 产品专利招聘 工艺管道招聘 绩效薪酬招聘 开发足疗招聘 模具零件招聘 器械培训招聘