The Faber laboratory focuses on improving and implementing targeted therapies to treat cancers, including Head and Neck, Lung, Breast and Nueroblastoma. We are seeing a postdoctoral Fellow to be involved in NCI-funded work in the fast-growing, well-funded VCU Philips Institute for Oral Health Research which is integrated into VCU Massey Cancer Center.
Responsibilities include: (1) Elucidating the biological mechanisms which lead to depressed BIM levels in oncogene-addicted cancer paradigms. Low BIM expression confers resistance to targeted therapies (for instance, Faber et al. Cancer Discovery 2011). Thus, the goal of this work is to define the mechanisms to which BIM is lowered in these resistant cancers, and to find pharmaceutical ways to de-repress BIM and sensitize these cancers to targeted therapies, with the aim to bring these new combination therapies into the clinic. (2) "Soft" bioinformatic approaches coupled with rigorous pre-clinical testing of novel therapies can lead to new targeted therapies in subsets of cancer (for example, Faber et al. Cancer Discovery 2014). These approaches include testing compounds in patient-derived xenografts and patient-derived cell lines, and this overall approach will be used to find novel targeted therapies in other paradigms.
Qualifications:Knowledge, Skills, Abilities (KSA's) and/or Competencies required to successfully perform work and Education, Experience, Licensure, Certification required for entry into the position.
Familiarity with establishing patient-derived cell lines from surgery or biopsies is a plus. In addition, advanced molecular and cellular biological techniques, such as PCR, cloning, Western blotting, immunoprecipitation, FACS assays including apoptosis and viability. siRNA transections and shRNA infections. Mammalian cell culture. Ability to work as a team and communicate effectively. Must be highly motivated. Ph.D. in cancer biology, biochemistry, microbiology. or a relevant Biological Discipline or equivalent training and experience. Several years experience in biological research setting where patient-derived cell lines are being established is a plus but not neccessary. Ability to work in a diverse environment is required.http://www.massey.vcu.edu/