英国医学研究会毒理学分会癌症生物学研究博士后职位

日期:2015-01-05
The Medical Research Council Toxicology Unit located at the University of Leicester is an internationally renowned institution delivering field-changing mechanistic insights into toxicology and disease.

Postdoctoral Scientist – (vacancy ref: IRC173873)
Fixed Term for 3 Years
Salary £28,648 – £30,486 per annum
Leicester

The Medical Research Council Toxicology Unit, located at the University of Leicester, is an internationally renowned institution delivering field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities and offers excellent opportunities for postdoctoral development. For more information see www.tox.mrc.ac.uk/

We are looking to appoint a postdoctoral scientist to join the scientific group led by Professor Gerry Melino working on cancer biology with a particular focus on the p53-family. Recent findings will expand the work on the metabolic aspects of cancer progression. The group was established in January 2004 and publishes extensively in high impact journals. There will also be the opportunity to collaborate with other groups within the Toxicology Unit (Anne E. Willis, Martin Bushell) and external laboratories (Tak W. Mak in Toronto, Doug R. Green in Memphis, Eleonora Candi in Rome, Karen H. Vosuden in Glasgow, Michael Karin in San Diego).

Project Outline
p53 tumour suppressor protein is critical in cancer biology for its role in cell cycle regulation, maintenance of genomic stability, metabolism and cell motility. Later discovered p53 homologues – p73 and p63 share remarkable structural and functional similarity with p53. Mutations of p53 and altered expression of p73 in cancer are associated to prognosis, chemo-resistance and metastasis.
By using different in vivo mouse cancer models (some of which have just been established in our laboratory) as well as in vitro cellular systems, the project will focus on high throughput genomics to identify the main alterations in the genomic networks associated to p53 family-dependent metastasis and chemo-resistance phenotypes.

The successful candidate will possess a PhD in a relevant discipline such as molecular biology or biochemistry and have experience of working with protein and RNA analysis, mammalian cell culture, transient & stable transfections and immunofluorescence. Applicants must be committed to working at a highly competitive level, be able to communicate scientific ideas effectively and have a proven publication record.

For an informal discussion about this position please contact Professor Gerry Melino: gm89@le.ac.uk OR ia119@le.ac.uk

Closing date for applications: 4th February 2015

Applications are handled by UK Shared Business Service; to apply please visit our job board at http://www.topcareer.jobs/Vacancy/irc173873_5023.aspx, please upload a CV & cover letter (saving the documents with reference IRC173873 included in the filename). Applicants who would like to receive this advert in an alternative format (e.g. large print, Braille, audio or hard copy), or who are unable to apply online should contact us by telephone on 01793 867003. Please quote the reference number.

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