The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. (HJF) is seeking a Post-doctoral Research Fellow to support the Military Enteric Diseases Research Program, located at the Naval Medical Research Center (NMRC) in Silver Spring, Maryland. HJF provides scientific, technical and programmatic support services to NMRC.
Specifically, the candidate will work on the Enterotoxigenic E. coli (ETEC) Vaccine Development Program. ETEC is a major global cause of childhood diarrhea and travelers’ diarrhea for which a safe, broadly protective vaccine has yet to be developed. Recently, NMRC completed a series of clinical trials with ETEC vaccine candidates that allow the development of methodologies and in-depth evaluation of cellular immunological mechanisms elicited by the vaccination. One of our main goals is the development and evaluation of assays that can help characterize the systemic and mucosal response to ETEC proteins.
Under the supervision and mentoring by the Head of Immunology, Clinical Trial Group, and Program Director, the incumbent will be responsible for conducting laboratory-based clinically relevant human immunologic research as well as assisting in designing, developing and executing research projects involving ETEC vaccine antigens supporting the ETEC Vaccine Development Program. In this capacity the incumbent will integrate immunological techniques and assays, mostly, but limited to, flow cytometry, ELISPOT, cell culture, and cytokine measurements. The successful candidate will have opportunity to participate in a parallel project involving systems biology (transcriptomics and proteomics) for the evaluation of clinical trials.
This is an ideal position for a young PhD (0-3 years) aiming at gaining hands-on experience in clinical trials, applied immunology, and vaccine development for enteric pathogens. Funds are available for up to three years, renewable yearly according to performance.
1. Plans, designs and conducts laboratory research focused on, but not limited to, human samples from ETEC Vaccine clinical trials.
2. Develops necessary technologies, protocols, and reports.
3. Assists in the preparation of funding applications for the U.S. Army Medical Research and Materiel Command, and/or extramural resources including nonprofit organizations.
4. Maintains expertise and knowledge of state-of-the-art principles and theories directly applicable to the research work being conducted. Should have knowledge and extensive experience in human cellular immunology, sterile tissue and cell culture, flow cytometry, ELISPOT, and familiarity in the field of mucosal immunology.
5. Performs data analysis, prepares graphical representation of data, prepares manuscripts for publication in peer reviewed scientific journals, prepares scientific reports for funded projects, presents research data at in-house meetings and at National and International scientific conferences.
6. Attends all training and safety classes conducted by NMRC and HMJF.
7. Completes other projects and duties as assigned
Required Knowledge, Skills, and Abilities: Knowledge of highly complex scientific procedures, techniques and fundamental; knowledge and practical experience in flow cytometry, cellular immunology, tissue culture, and cytokine measurement; Practical experience in immunization and isolation of organs from small animals is helpful. Should have excellent communication skills including the ability to write and publish research papers and grants. Should have the ability to work independently and troubleshoot technical procedures.
Minimum Education/Training Requirements: 0 to 3 years of Ph.D. in Immunology or related scientific discipline with strong experience in cell assays.
Minimum Experience in cell assays, including polychromatic flow cytometry, ELISPOT, lymphocyte culture and cytokine assays, and vocational interest in vaccine development.
Physical Capabilities: Work involves long periods of standing, handling numerous chemicals and biological samples.
Work Environment: Laboratory environment; requires working with human cells and plasma/serum; may require working long hours including evenings and weekends.
Please apply on-line at careers.hjf.org click “Advanced Search” and enter job number 209447 in the Job Opening ID box.
HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, protected veteran status or other status protected by law
The Henry M. Jackson Foundation