印第安纳大学医学院寄生虫研究博士后职位

日期:2015-01-06
Multiyear post-doctoral position available to investigate the role of a calcium dependent protein kinase in the lytic and developmental cycles of the obligate intracellular parasite Toxoplasma gondii.

Multiyear post-doctoral position available to investigate the role of a calcium dependent protein kinase in the lytic and developmental cycles of the obligate intracellular parasite Toxoplasma gondii. Related to the malaria parasite, Toxoplasma causes serious disease in immuno-compromised (AIDS) patients and during pregnancy. We have shown that disruption of TgCDPK3, a member of a kinase family not present in mammalian cells, affects the replication of the parasite and its ability to establish a chronic infection in vivo. Potential projects include monitoring propagation of mutant parasites in infected animals, characterizing TgCDPK3 substrates during the chronic stage, investigate growth of parasite within immune cells and determining the role of TgCDPK3 in parasite division. Position requires a Ph.D., expertise in biochemistry, molecular and cellular biology, and excellent communication skills (speaking and writing English). Experience in molecular parasitology, kinases, calcium signaling, in vivo experiments, or immunology is a plus. Submit cover letter, which must include research project ideas, CV, and contact information for three references to Dr. Gustavo Arrizabalaga (garrizab@iu.edu). …

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