A postdoctoral position is available in the laboratory of Dr. Hind Medyouf at the Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt, Germany.
Dr. Medyouf has a long-standing interest in investigating the molecular mechanisms underlying blood cancers (Medyouf et al., Nat. Med 2007; Blood 2010; JEM 2011; Cell Stem Cell 2014). Her newly established laboratory is more specifically focused on how specific cellular elements and molecular pathways within the bone marrow microenvironment can contribute to the pathogenesis and progression of hematological cancers.
The proposed project aims to decipher the interplay between hematopoietic and niche cells in the pathogenesis of human myelodysplastic syndromes (MDS), as well as their progression to acute myeloid leukemia or bone marrow failure.
MDS are a heterogeneous group of clonal diseases, mainly affecting the elderly and characterized by ineffective production of mature blood cells, with frequent progression to bone marrow failure (2/3 MDS cases). As such, most MDS patients rely on frequent blood transfusions, a procedure that often results in significant complications. In about 1/3 of MDS cases, the disease progresses to full-blown acute myeloid leukemia, which is particularly difficult to treat. The only potential cure for MDS patients is hematopoietic stem cells (HSC) transplantation, which is limited to younger patients with suitable matching donorshttp://www.nature.com/naturejobs/science/jobs/485931-erc-funded-postdoctoral-position-to-investigate-the-role-of-the-microenvironment-in-leukemias