The Molecular Microbiology of Actinomycetes team is part of the newly created Institute of Integrative Biology of the Cell (I2BC). It is located in the University Paris Sud, in Orsay, in the south of Paris (France).
Our team is mainly interested in the secondary metabolism of Streptomyces species (http://www.igmors.u-psud.fr/spip.php?article1572). Our approaches vary from the detailed investigation of gene clusters of specific natural product families (diketopiperazines, pyrrolamides) to a more global (genomic) study at the strain level. We are also developing synthetic biology approaches for the development of new biologically active metabolites.
A postdoctoral position is available in our laboratory to work on the synthetic biology of two families of natural products, the pyrrolamides and the aminoglycosides. The research project aims at increasing the chemical diversity of these natural products and at improving the currently limited understanding of the key factors influencing the outcomes of combinatorial biosynthesis and mutasynthesis. This project will be carried out in collaboration with chemists from the team of Laurent Micouin (Université Paris Descartes, Paris). The position, which is available from April 2015, is funded by the French National Research Agency for 32 months.
Desired skills and experience
We are looking for highly motivated candidates who have completed their PhD in life sciences. The successful applicant must have a strong background molecular biology and microbiology. Experience in microbial natural products biology and chemistry (purification and analysis) is desirable. Experience in protein purification would be appreciated.
Please send your application with a cover letter and CV to Dr Sylvie Lautru (including a list of publications and contact information of 2-3 referees). …