Highly qualified and motivated postdoctoral associates are sought to join the laboratory of Dr. Paolo Provenzano at the University of Minnesota in Minneapolis, MN. Our laboratory studies the physical and molecular mechanisms driving cancer progression to metastasis and resistance to therapeutic intervention, and develops therapeutic strategies directed against the stroma. Our focus is largely directed toward the study of breast and pancreatic cancer as the outcome for patients with metastatic breast cancer remains poor, while pancreatic ductal adenocarcinoma is, with rare exception, a uniformly lethal disease that is resistant to all conventional chemo and radiotherapies. Therefore, to answer fundamental questions in cancer biology and oncology we interface a bioengineering and cell and molecular biology research approach. Advanced quantitative imaging, cell and matrix mechanics, tissue engineering and cell and molecular biology techniques are utilized extensively (for example Cancer Cell, 21(3), 418-429, 2012; Oncogene 28(49): 4326-4343, 2009; Biophysical Journal, 95: 5374-5384, 2008). Our goals are to use these platforms to elucidate the fundamental mechanisms of disease progression and develop novel therapeutic strategies.
Two areas of inquiry are being actively pursued:
1) Dissect the physical and molecular mechanisms by which matrix architecture and stiffness influence distinct tumor cell populations and their interactions during disease progression to metastasis.
2) Develop and test strategies to target the stromal compartment in order to impede disease progression and/or enhance transport of small molecule therapies.
A Ph.D. in the field of Biomedical Engineering, Biophysics, Cell Biology, Immunology, or a related field and a demonstrated, published, track record of productive research experience. For the cancer bioengineering position a background in engineering or another physical science field or quantitative biology is desired. For the cancer biology position, backgrounds in all fields of biology will be considered. Candidate must be experienced in essential techniques in molecular and cellular biology such as tissue culture, transfection / infection of cells, PCR, Western blotting, IHC and IF. Successful candidates must have excellent communication and organizational skills, the ability to develop creative approaches to experimental design and be able to work collaboratively. Candidates with additional experience in advanced imaging techniques, tissue engineering, modeling, or immunology are strongly encouraged to apply.
About the Provenzano lab
The Provenzano laboratory is both an engineering and biology laboratory and is fully equipped for routine cell and molecular biology work, experimental mechanics, and computational anaylsis. In addition, the Provenzano lab has a our own multiphoton laser-scanning microscope, with FLIM and PLIM detection and full photoactivation control, and is specially designed for intravital imaging experiments. Our laboratory is part of the Department of Biomedical Engineering (a top 25 ranked department) and the Masonic Cancer Center (an NCI designated Comprehensive Cancer Center) at the University of Minnesota (a vibrant research environment and an excellent setting for biomedical research, currently ranking 8th among public universities and 13th overall in research expenditures; 2012 National Science Foundation report). In addition, Dr. Provenzano is a full member faculty of the prestigious Stem Cell Institute and a member of the Institute for Engineering in Medicine. Collectivity, these interactions provide critical support to our research program and represent a scientifically robust community that fuels our interdisciplinary research program. See provenzanolab.umn.edu for additional information.
To inquire or apply please write to firstname.lastname@example.org with the subject line:
Cancer Bioengineering/Biology Postdoctoral Position. Please include an up to date CV, (1-2 relevant publications) and a brief description of your research interests and relevant background as related to our research program and your near term and long term goals. Letters of reference may be requested at a later date….