A post-doctoral position is available in Dr Sally Dawson’s lab at the UCL Ear Insitute, University College London working on a project entitled “Investigating the Genetic Basis of Otosclerosis” in collaboration with Prof Shak Saeed.
Our work focuses on the causes of adult onset hearing loss. Otosclerosis is a condition affecting the stapes bone of the middle ear leading to a conductive hearing loss with a typical age of onset in young adults. In about 25% of cases the condition is familial with a dominant inheritance that exhibits variable penetrance. The successful applicant will use a whole-exome sequencing approach to identify the genes which underlie familial otosclerosis followed by functional charaterisation of the molecular mechanisms involved in the dysregulated bone growth. Additional approaches will include gene expression analysis of affected stapes tissue removed from patients and an investigation of the effects of mutations on gene function.
The Ear Institute ( http://www.ucl.ac.uk/ear ) is a multi-disciplinary facility with the remit of “understanding hearing and fighting deafness” adjacent to the Royal National Throat, Nose and Ear Hospital. Facilities at the Ear Institute are world-class, and will enable all of the components of the project to be undertaken to a high level.
Funding is available for 3 years from Action on Hearing Loss (http://www.actiononhearingloss.org.uk/) with a start date of March/April 2015. Applicants must hold or expect to hold a PhD in molecular genetics and have experience of relevant techniques such as gene expression analysis, mutation analysis and genetic analyses.
Applicants must hold or expect to hold a PhD in molecular genetics and practical experience with at least some of the techniques used in the project (PCR, qPCR, genotyping, analysis of whole exome sequencing data, RNA and gDNA preparation, mutation analysis, cell culture and transfection, association studies).
Applicants should apply online. Please click the ‘Apply’ button below.
For more information about the project please contact Dr Sally Dawson (email: firstname.lastname@example.org )