The lab: The Apostolou group studies the molecular mechanisms governing cell fate changes during somatic cell reprogramming and differentiation. Specifically, we investigate the interplay among three-dimensional chromatin architecture, transcription factors and epigenetic regulators and their effect on gene expression and cell identity. We use high-throughput sequencing techniques such as 4C-Seq, HiC, ChIP-seq and RNA-seq, as well as biochemical, molecular and cell biology assays and novel mouse genetics tools. Among other questions, we ask how dynamic chromatin rearrangements are implicated in physiological or pathological cell fate alterations, such as cancer.
The position: The successful candidate will join a thriving team of researchers, including molecular, stem cell and computational biologists. He/she will be part of a collegial supportive environment and will enjoy state-of-the art facilities and collaborative interdisciplinary opportunities within Weill Cornell Medical Center (WCMC) as well as Rockefeller University and Memorial Sloan Kettering Hospital.
1) A PhD degree in Biology, Biochemistry or related field.
2) Strong background in Molecular Biology, Cell Biology, Mouse Genetics and Biochemistry
3) Experience in ChIP, microarray assays and in high throughput sequencing technologies (library preparation for ChIP-seq, RNA-seq etc).
4) Experience in mouse handling, breeding, tissue isolation and mammalian cell culture.
5) An ability to work independently and be an enthusiastic scientist, with excellent communication skills (professional proficiency in written and spoken English required).
6) Applicants should send a cover letter, their curriculum vitae and contact information for at least two referees to firstname.lastname@example.org
HIGHLY DESIRED SKILLS AND ABILITIES
Strong publication record.
Experience with single-cell imaging, such as in situ hybridization
Collaborative spirit and passion for innovation.
Strong sense of responsibility.