威康信托桑格研究所代谢生物信息学研究博士后职位

日期:2015-01-08
We are currently seeking applicants for a Statistician position at the Soranzo group

Postdoctoral Fellow in Metabolomics Bioinformatics or Computational

Salary £30,202 to £37,860 dependent on experience
Fixed Term Contract: 3 years

We are currently seeking applicants for a Statistician position at the Soranzo group (https://www.sanger.ac.uk/research/faculty/nsoranzo/) at the Wellcome Trust Sanger Institute (WTSI located on the Wellcome Trust Genome Campus near Cambridge in the UK. The post will suit an ambitious and talented statistician, who is interested in applying their skills in the genetics/genomics field.

The project is funded by the Centre for Therapeutic Target Validation (CTTV), a collaboration between EMBL-EBI, the WTSI and GlaxoSmithKline (http://www.targetvalidation.org/). This is a public-private initiative to generate evidence on the validity of therapeutic targets, and is committed to sharing its data openly with the scientific community.

The successful candidate will be involved in statistical analyses of large-scale metabolomics datasets and whole-genome sequencing data. The aims of this work are to identify genetic variants associated with metabolomic levels, and ultimately to translate these findings into new opportunities for drug development in cardiometabolic disease.
The selected candidate will work with an interdisciplinary team of scientists, bioinformaticians and statisticians at the Wellcome Trust Sanger Institute (WTSI). The WTSI, which is based on Europe’s largest genomics campus (near Cambridge), focuses on understanding the role of genetics in health and disease. Dr Nicole Soranzo leads a group focusing on the use of quantitative intermediate traits (such as haematological and metabolomic traits) to unravel novel mechanisms underlying common, complex diseases such as cardiovascular disease. The project will also involve collaboration with the Cardiovascular Epidemiology Unit (CEU), Department of Public Health and Primary Care, University of Cambridge. The CEU conducts world-leading interdisciplinary research with a major focus on the prediction and prevention of cardiovascular diseases using studies conducted in more than 2.5 million participants. Professor John Danesh is the Unit's overall Director, and Dr Adam Butterworth leads the cardiovascular statistical genetics. More information about our collective interests and activities can be found at, http://www.phpc.cam.ac.uk/ceu/. Additional collaborators on the project are Prof. George Davey-Smith (School of Social and Community Medicine, University of Bristol, http://www.bris.ac.uk/social-community-medicine/people/george-davey-smith/index.html) and Prof. Brent Richards (McGill University, http://www.mcgill.ca/genepi/richards-lab).

The post-holder will be expected to lead analyses of common and rare genetic variation with the high-dimensional metabolomic dataset, including traditional single variant analyses, gene-based tests, data reduction techniques, and extensions to causal inference (“Mendelian Randomisation”) approaches. There will also be opportunities to contribute to development of novel methods. The work of the post-holder is expected to lead to high-impact publications.

Essential Skills
The post-holder will have: (1) relevant qualifications eg, a PhD in statistics, biostatistics, statistical genetics, or another quantitative discipline. A degree in pharmacological science with substantial experience in computational and statistical projects will also be considered. (2) a sound understanding of statistical concepts, ideally in relation to chronic disease epidemiology/quantitative traits (3) strong quantitative and computational skills, including experience of using relevant statistical software (eg, STATA, R, and ideally also a programming language such as Python, Perl or C++) (4) high level report writing and presentational skills (5) a working knowledge of genetics is desirable but not essential. Since the post holder will be primarily responsible for driving this project and for liaising with other members of the WTSI and CEU group, he/she should also be able to work independently, accurately judge priorities, and have excellent organisational, communication and leadership skills.

Other information
The Genome Campus is a 100-acre estate south of Cambridge in the grounds of Hinxton Hall. Nestled in the quiet countryside of these landscaped gardens, are two world-class research facilities: the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

In addition to its peaceful location the campus offers excellent facilities including a state of the art data centre, gym, two cafes, a nursery, dining facilities, a cycle to work scheme, car sharing and free campus buses from various locations around Cambridge.

Through the extensive seminar programme the Institute manages a range of scientific seminars with internal and externally invited speakers, scientific group meetings and skills development workshops. This aids learning, development and networking which are important aspects of life on campus.

Equally important to campus life is the social activities offered by the Sports and Social Club whether it is a 'Burns night supper', the Mid-summer Ball or a quiz night there are opportunities to meet with people working across the organisation.

The Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and Annual Leave 25 days plus Bank Holidays.
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training.

Closing Date for applications: 8th February 2015

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