Contract Type: Fixed-term until 31 May 2016
Faculty: Faculty of Medicine Dentistry & Health
The Department of Oncology, Academic Unit of Inflammation & Tumour Targeting is seeking to appoint an experienced Post-doctoral Research Associate to join the team led by Professor Claire Lewis. The group conducts research into the role of inflammatory cells called macrophages in the response of primary and metastatic tumours to chemotherapeutics agents (De Palma & Lewis. 2013. Cancer Cell). They have also developed a way to use these cells to deliver oncolytic viruses to tumours (Muthana et al. 2011 & 2013. Cancer Research).
In an exciting extension of the latter project, the appointee will work as part of small team within Professor Lewis’ lab attempting to insert such an oncolytic virus into human CD34+ haematopoietic stem cells ex vivo and then repopulate the bone marrow with these cells. It is hoped that this new approach will furnish the body with a constant supply of virally-loaded macrophages (which then continually develop from these stem cells in the bone marrow). These ‘armed’ cells should then kill tumour cells wherever they then develop in the body.
The project (StemCure) involves collaborations with a number of other labs including that of Dr Andy Chantry in the Oncology Dept in Sheffield.
The successful candidate will have a PhD and preferably, 2 to 3 years’ experience in haematopoietic stem cell biology, molecular biology and/or virology.
Please note that from 5pm on Thursday 8 January 2015 until 9am on Tuesday 13 January 2015, our recruitment system will be unavailable due to essential maintenance. During this period you will not be able to search or apply for jobs, access your Candidate Profile or track applications.http://www.jobs.ac.uk/job/AKH643/postdoctoral-research-associate/