烈日大学恶性T细胞淋巴瘤研究博士后职位

日期:2015-01-10
The Immunology-Vaccinology unit of the FARAH research center at the University of Liège (ULg Belgium) has a strong expertise in studying gammaherpesvirus infection in animal models.

Defining malignant catarrhal fever as a peripheral T cell lymphoma
Description
The Immunology-Vaccinology unit of the FARAH research center at the University of Liège (ULg, Belgium) has a strong expertise in studying gammaherpesvirus infection in animal models. Benjamin Dewals leads one of the three groups of the Immunology-Vaccinoogy unit. The group focuses on the pathogenesis of alcelaphine herpesvirus 1 (AlHV-1)-induced malignant catarrhal fever (MCF). Recent findings from the research group have demonstrated that MCF induced by AlHV-1 in cows is dependent on virus latency establishment and maintenance in a population of activated CD8+ T cells (Palmeira et al., PNAS, 2013, Dewals et al., J. Virol, 2011, Dewals et al., Vet Res, 2011, Dewals et al., 2008). The results strongly suggest that MCF is a peripheral T cell lymphoma-like disease induced during latency in T cell lymphocyte. However, the mechanisms causing cell activation and proliferation in MCF-susceptible species cells are yet to be determined. The successful candidate will be involved in this research project and will work in close collaboration with other PhD students and postdocs under the direct supervision of Dr Benjamin Dewals. Joining our research group will offer the unique possibility to explore the pathways involved in the activation of latently infected CD8+ T cells in bovine and in the rabbit model. We will combine basic immunology tools with cell biology and molecular biology approaches including RNAseq analyses and phospho-proteomics approaches to understand how AlHV-1 induces the activation and proliferation of CD8+ T cells and how MCF relates to peripheral T cell lymphomas. You will become part of a young, international and highly motivated team in the stimulating scientific environment of the FARAH research center. The FARAH has biweekly seminars by keynote national and international speakers. You will have direct access to and training in many cutting edge technologies, like BAC technology, multi-colour flow cytometry, advanced cell sorting. Profile: -Candidates should have a PhD in Virology, Immunology or a related field obtained 5 years ago maximum. Candidates must be non-Belgian citizens and should not have lived and/or worked in Belgium for more than 24 months during the past 3 years. - In vivo experience with animals (bovine and rabbits) and knowledge of basic immunology tools, like flow cytometry, is absolutely required. - Skills in bioinformatic analyses and data mining will be an asset for selection. - Candidates should have a strong publication record, which will allow them to apply independently for grants - Candidates should have excellent communication skills in spoken and written English - He/she is capable of working in a team, as well as independently, has an open communication style and has a problem-solving attitude How to apply? Candidates can send a motivatio

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