鲁汶大学1型糖尿病研究博士后职位

日期:2015-01-10 点击:
Applications are invited for a postdoctoral position at the Laboratory of Experimental Medicine and Endocrinology at the Catholic Universityof Leuven Leuven Belgium for a project on 'The beta-cell in the pathogenesis of type 1 diabetes: role of endoplasmic reticulum chaperones in the interaction between the beta-cell and the immune system.'

Applications are invited for a postdoctoral position at the Laboratory of Experimental Medicine and Endocrinology at the Catholic Universityof Leuven, Leuven, Belgium for a project on 'The beta-cell in the pathogenesis of type 1 diabetes: role of endoplasmic reticulum chaperones in the interaction between the beta-cell and the immune system.'
Description
Prof Chantal Mathieu's research team focuses on the pathogenesis of type 1 diabetes (T1D). Research areas of interest are in particular focusing on the special nature of the beta-cell, it's possible role in its own destruction and more recently the specific role of inflammation-mediated post-translational modifications in the generation of beta-cell neo-autoantigens. Also her lab is well equipped for performing preclinical studies making use of animal models in T1D and especially demonstrating the value of the vitamin D hormone as a natural immune modulator. Recently her team also brought antigen-specific therapies into a new dimension by oral delivery of antigens through genetically modified Lactococcus lactus bacteria. Recent research in the Mathieu lab has demonstrated that the endoplasmic reticulum chaperone GRP78 is translocated to the beta-cell plasma membrane and is post-translationally modified by citrullination upon inflammatory stress (Rondas D et al, Diabetes, 2014). The postdoctoral candidate will work further on this line of research, and will work in close collaboration with other PhD students, postdocs and technicians, under the direct supervision of Dr. Lut Overbergh. He/she will combine basic molecular work with cell biology, in vivo mouse work and immune approaches, to better understand the mechanisms involved in the interaction between beta-cell and immune system. An overview of our recent research in this area can be read in D'Hertog W et al. Mol Cell Proteomics 6(12), 2180-2199 (2007); D'Hertog W et al J Prot Res, 9(10), 5142-5152 (2010); Dunne J et al. Diabetes, 61(8), 1907-1914 (2012); Rondas D et al. J Prot Res, 12(9), 4193-4206 (2013); and Rondas D et al. Diabetes Epub ahead of print (2014).
Benefits
- 1 year postdoctoral position, with possibility of extension
Additional Job Details
Reference number BAP-2014-581 - Candidates must have a PhD in the field of biological, biomedical, medical sciences or equivalent. He/she is a junior postdoctoral fellow who received his/her PhD within the last 3 years. - He/she has an excellent background in molecular and cell biology. - In vivo experience with mice, knowledge of basic immunology tools and experience in diabetes research are an important asset. - The candidate has a strong publication record, which will allow him/her to apply for a personal postdoctoral grant. - The candidate has excellent communication skills in written and spoken English. - He/she is highly motivated to work in a multidisciplinary research team, as well as independently, has an open communication style and has a problem-solving attitude. For more information please contact Mrs. Lut Overbergh, tel.: +32 16 37 74 66, mail: lutgart.overbergh@med.kuleuven.be or Prof. dr. Chantal Mathieu, tel.: +3216346023, mail: chantal.mathieu@med.kuleuven.be. You can apply for this job no later than 15/02/2015 via the online application tool

微信扫一扫分享资讯

相关阅读
鲁汶大学结构蛋白质组学研究博士后职位
巴斯德研究所老龄化研究博士后职位
西班牙基因组调控中心生物化学研究博士后职位
纳菲尔德骨科细胞免疫学研究博士后职位
南安普顿大学神经免疫学研究博士后职位
布里斯托大学感染初级护理研究博士后职位
哪四类求职者最让人反感?

不要做让HR管理者反感的人,要做一个让HR管理者欣赏的人。如果你有以上的坏毛病,一定要改正,因为这些坏毛病会阻碍到你求职,影响到你以后在职场上的发展。

合肥市口腔医院急聘口腔专业博士、硕士

安徽省内唯一一家三级口腔专科医院,创建于1956年,历经六十年的风雨兼程,已发展成为集医、教、研、防为一体的现代化口腔专科医院,并形成了“一院、两区、三部”的格局,现在面向全国急招口腔方面专业人才,欢迎您的投递!

医疗助理招聘 医学翻译招聘 美容科专家招聘 学术推广招聘 百科总监招聘 代谢研发招聘 海上平台招聘 检测专业招聘 课程导师招聘 农药注册招聘