Applications are invited for a postdoctoral position at the Laboratory of Experimental Medicine and Endocrinology at the Catholic Universityof Leuven, Leuven, Belgium for a project on 'The beta-cell in the pathogenesis of type 1 diabetes: role of endoplasmic reticulum chaperones in the interaction between the beta-cell and the immune system.'
Prof Chantal Mathieu's research team focuses on the pathogenesis of type 1 diabetes (T1D). Research areas of interest are in particular focusing on the special nature of the beta-cell, it's possible role in its own destruction and more recently the specific role of inflammation-mediated post-translational modifications in the generation of beta-cell neo-autoantigens. Also her lab is well equipped for performing preclinical studies making use of animal models in T1D and especially demonstrating the value of the vitamin D hormone as a natural immune modulator. Recently her team also brought antigen-specific therapies into a new dimension by oral delivery of antigens through genetically modified Lactococcus lactus bacteria. Recent research in the Mathieu lab has demonstrated that the endoplasmic reticulum chaperone GRP78 is translocated to the beta-cell plasma membrane and is post-translationally modified by citrullination upon inflammatory stress (Rondas D et al, Diabetes, 2014). The postdoctoral candidate will work further on this line of research, and will work in close collaboration with other PhD students, postdocs and technicians, under the direct supervision of Dr. Lut Overbergh. He/she will combine basic molecular work with cell biology, in vivo mouse work and immune approaches, to better understand the mechanisms involved in the interaction between beta-cell and immune system. An overview of our recent research in this area can be read in D'Hertog W et al. Mol Cell Proteomics 6(12), 2180-2199 (2007); D'Hertog W et al J Prot Res, 9(10), 5142-5152 (2010); Dunne J et al. Diabetes, 61(8), 1907-1914 (2012); Rondas D et al. J Prot Res, 12(9), 4193-4206 (2013); and Rondas D et al. Diabetes Epub ahead of print (2014).
- 1 year postdoctoral position, with possibility of extension
Additional Job Details
Reference number BAP-2014-581 - Candidates must have a PhD in the field of biological, biomedical, medical sciences or equivalent. He/she is a junior postdoctoral fellow who received his/her PhD within the last 3 years. - He/she has an excellent background in molecular and cell biology. - In vivo experience with mice, knowledge of basic immunology tools and experience in diabetes research are an important asset. - The candidate has a strong publication record, which will allow him/her to apply for a personal postdoctoral grant. - The candidate has excellent communication skills in written and spoken English. - He/she is highly motivated to work in a multidisciplinary research team, as well as independently, has an open communication style and has a problem-solving attitude. For more information please contact Mrs. Lut Overbergh, tel.: +32 16 37 74 66, mail: firstname.lastname@example.org or Prof. dr. Chantal Mathieu, tel.: +3216346023, mail: email@example.com. You can apply for this job no later than 15/02/2015 via the online application tool