A 36 months postdoctoral position, funded by the Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases (LabEx IBEID: http://www.pasteur.fr/labex/ibeid), is available in the "Functional Genetics of Infectious Diseases" research unit directed by Anavaj Sakuntabhai at the Institut Pasteur in Paris. The work will be in collaboration with Frederic Ariey, Genetics and Genomics of Insect Vectors Unit, Institut Pasteur.
It is well accepted that the outcome of infection in malaria depends upon interaction between the human host and Plasmodium spp. This is the result of forces of selection and escape acting on the two genomes over evolutionary time. Although the parasite goes through several stages in the human host, the best characterized point of contact between the parasite and host at the molecular level is the entry of merozoites into the red blood cell, involving multiple receptor (human)-ligand (parasite) interactions that have been characterized by in vitro studies. Other interactions are likely to result in more subtle effects on infection outcome that can be explained by particular human-parasite polymorphism configurations. With the advent of high throughput genotyping and whole genome sequencing, it is now possible to envisage undertaking studies that cross human variability against parasite variability in a global fashion. The aim of this project is to develop and apply such methods appropriate for host-parasite interactions in the context of human infection by P. falciparum.
Additional Job Details
Candidate requirements: The successful candidate is expected to have a solid background in human or plasmodium genetics/genomics and expertise knowledge in bioinformatics, ability to perform statistical genetics analyses or phylogenic analysis, good communication skills and a demonstrated desire to work on interdisciplinary problems. Requirements: PhD in relevant field - Appropriate experience in research and high motivation - Excellent scientific, organizational skills, reliable person - Initiative and independent work abilities - Excellent interpersonal and scientific communication skills, able to work in collaboration - Good English language skills for presentations and writing scientific papers To apply: Applicants should send their CV, a motivation letter and 3 references to Anavaj Sakuntabhai (firstname.lastname@example.org) Functional Genetics of Infectious Diseases Unit, Institut Pasteur, 28 rue du Dr Roux 75015 Paris