俄勒冈健康科学大学癌症干细胞生物学研究博士后职位

日期:2015-01-12
Postdoctoral position is available for highly motivated candidates with a background in stem cell biology/cancer/developmental biology to join the Shin laboratory in the Department of Cell Developmental and Cancer Biology/Knight Cancer Institute at Oregon Health and Science University (OHSU).

Postdoctoral position is available for highly motivated candidates with a background in stem cell biology/cancer/developmental biology to join the Shin laboratory in the Department of Cell, Developmental, and Cancer Biology/Knight Cancer Institute at Oregon Health and Science University (OHSU).

Our current research focuses on Hedgehog (Hh) signaling and its role in tissue maintenance/regeneration and cancers of various organs. The major focus of current research is to understand how Hh signaling and its interaction with other developmental pathways, especially pathway interaction between stem cells and their microenvironment, control the physiology of stem cells during regeneration, and how dysregulation of these pathways plays a role in various pathological conditions in endodermal-derived epithelial tissues (Shin et al, Nature 2011; Shin et al, Nat. Cell. Biol. 2014; Shin et al, Cancer Cell 2014; Lim et al, Nat. Cell. Biol. 2014). Lab website: www.ohsu.edu/cdcb/shin. Job: IRC44701

Shin K*, Lim A, Zhao C, Sahoo D, Pan Y, Spiekerkoetter E, Liao JC, Beachy PA*. Hedgehog signaling restrains bladder cancer progression by eliciting stromal production of urothelial differentiation factors. Cancer Cell. 2014 Oct 13;26(4):521-33. PMID: 25314078. *Co-corresponding authors.

Lim, A$, Shin K$,, Zhao, C, Kawano, C, Beachy PA. Spatially restricted Hedgehog signaling regulates HGF-induced branching of the adult prostate. Nat Cell Biol. 2014 Dec;16(12):1135-45. PMID: 25362352. $Co-first authors. *Co-corresponding authors.

Shin K*, Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA*. Cellular Origin of Bladder Neoplasia and Tissue Dynamics of its Progression to Invasive Carcinoma. Nat. Cell Biol. 2014 Apr 20 | doi:10.1038/ncb2956. *Co-corresponding authors.

Shin K*, Lee J, Guo N, Kim J, Lim A, Qu L, Mysorekar IU, Beachy PA*. Hedgehog/Wnt Feedback Supports Regenerative Proliferation of Bladder Stem Cell. Nature. 2011 Apr 7;472(7341):110-4. * Co-corresponding authors. Recommended by Faculty of 1000.

Applicants should hold a PhD degree and have strong background in stem cell and cancer biology. Significant experience in the following areas is required: Molecular and cell biology, epigenetics, mouse genetics and in vivo mouse models. Ability to communicate in written and spoken English is required.

Interested candidates should submit a full application including a cover letter, curriculum vitae, and names and contact information (email and telephone numbers) of three references by email to shink@ohsu.edu.

For more information about this position, please contact Dr. Kunyoo Shin (shink@ohsu.edu), assistant professor in the Department of Cell and Developmental Biology/Knight Cancer Institute at OHSU.

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