法国ENS研究所凋亡研究博士后岗位

Institution

École Normale Supérieure (ENS) ，France

Position

Post doctoral position available on Drosophila apoptosis

Location

Lyon, France

Date Posted

August 23

Description

Apoptosis is a form of physiological cell death that is essential for normal development and homeostasis. Apoptosis needs to be tightly regulated, and its deregulation may lead to cancer (lack of apoptosis) or degeneration (excess of apoptosis).
To study the mechanisms controlling cell death in a terminally differentiated neuron, we have established a neurodegenerative model in differentiated Drosophila photoreceptor cells (PRs). We conducted a dominant modifier screen of dp53-induced PR death. Using a P-element lethal collection, we have isolated 31 candidate genes, in which mutations enhance or suppress dp53-induced cell death. Among those genes, we have characterized the role of cytochrome-c-d in the regulation of apoptosis in the retina (Mendes et al. 2006). We are pursuing the characterization of the genes isolated in the screen with a particular focus on the roles of oxidative and endoplasmic reticulum stresses on apoptosis.

The CNRS ATIP program provides salary for a foreign (non-French citizen) post-doctoral fellow. Salary based on experience.

About the Institute: The École Normale Supérieure (ENS) is well known in France and has a solid international reputation among leading scientific institutions, making it a top choice for graduate students and post-docs. The ENS is also a nationally renowned teaching Institution. With its very competitive national entry exam, the ENS Lyon selects outstanding undergraduate and graduate students. http://www.ens-lyon.fr/LBMC/index-uk.htm

About the city: Located in the center of Europe, Lyon is the second French biggest city, 2 hours south of Paris by TGV (fast train), 2 hours from Italy or Switzerland and 3 hours from Spain.
http://www.en.lyon-france.com/ http://www.lyon-photos.com/diaporama/index_fetelumieres2006_43.htm

Contact

Professor Bertrand Mollereau
ATIP group “Apoptosis and Neurogenetics” LBMC
Ecole Normale Supérieure of Lyon
France

Send CV and 3 letters of reference to bertrand.mollereau@ens-lyon.fr