法国国家科研中心细胞生物物理学研究博士后岗位

Institution

Centre National de la Recherche Scientifique and Université Paris 7 (http://www.msc.univ-paris7.fr)

Position

Post-doc position in cell biophysics

Location

Paris - France

Date Posted

Oct 13th 2007

Description

Title : MICROMECHANICAL STUDY OF INTERACTIONS BETWEEN CADHERINS AND INTEGRINS

The issue is to understand how cell-cell and cell-matrix adhesive contacts are coupled to modulate the cell adhesion status and its mechanical properties. Using a panel of complementary micromechanical tools (optical tweezers, cell uniaxial stretching, micropatterned adhesive substrates) and visualization techniques, together with molecular biology tools, the project will consist in studying the mechanisms responsible for the growth or for the disruption of intercellular contacts mediated by cadherins. It will especially focus on the structural changes and rigidity variations of these intercellular contacts, induced by a controlled modulation of the density and of the spatial distribution of adhesive cell-matrix contacts. The reciprocal crosstalk (perturbation of cell-matrix contact due to intercellular adhesion) will also be considered. The work will be held in collaboration with a group of biologists at Institut Curie (Paris). The project is granted by the program “Physique et Chimie du Vivant” of the French Agence Nationale de La Recherche.

Candidates are expected to have a high level background in physics/biophysics, to be enthusiastic and motivated for a collaborative experimental work associating physicists and biologists. Ideally, they should have experienced research in the domain of cell adhesion, cytoskeleton structure and mechanical properties.

Contact

Please send CV, cover letter describing previous work and experience, names and e-mail addresses of referees able to provide recommendation, to :
Prof. François GALLET
Matière et Systèmes Complexes
Batiment Condorcet – Case 7056
Université Paris-Diderot (Paris 7)
10 rue Alice Domon et Léonie Duquet
F-75205 Paris cedex 13
francois.gallet@univ-paris-diderot.fr
http://www.msc.univ-paris7.fr//English/site/index.html
http://www.msc.univ-paris7.fr/pages-perso/gallet/