荷兰乌特勒支大学医学中心肿瘤生物学博士后岗位
日期：2007-11-23
来源：丁香人才网
InstitutionUniversity Medical Center UtrechtPositionPostdoc position in cancer biology at University Medical Center Utrecht The NetherlandsJob Number4002383Date PostedNov 22th 2007Application Deadline ...
Institution
University Medical Center Utrecht
Position
Postdoc position in cancer biology at University Medical Center Utrecht,The Netherlands
Job Number
4002383
Date Posted
Nov 22th 2007
Application Deadline
Open Until Filled
Description
Project description:
Metastases formation is a major factor in disease progression andaccounts for the majority of cancer deaths. The molecular mechanismscontrolling invasion, dissemination to blood or lymphatic systems andtumor spread of tumor cells to distant organs are still poorlyunderstood. Recent observations indicate that the metastatic phenotypemay already be present during the angiogenic switch of tumors. One ofcrucial rate-limiting events during human tumor growth is encounteredwhen tumors outgrow the pre-existing vasculature leading to hypoxia(oxygen insufficiency).
Intratumoral hypoxia is a hallmark of solid cancers. Hypoxic tumors havea higher tendency to metastasize and are clinically characterized bytherapy resistance and a poor prognosis. The Hypoxia Inducible Factors(HIF) are key molecules in the hypoxic response and play critical rolesduring tumor cell expansion by regulating energy metabolism and theinduction of angiogenesis. Our lab recently identified TWIST1: anoncogene involved in resistance to apoptosis and inducer ofepithelial-to-mesenchymal transition as a key target of HIF.
This main topics of this project are.
1. Further characterization of the role of TWIST1 in hypoxia response invitro and in vivo
2. Clonal analysis (Molecular imaging) of hypoxic tumor cells in vivo.
3. Development of therapeutic antibodies to eliminate hypoxic tumor cellin vivo.
Terms and conditions:
A postdoctoral position with a maximum gross monthly salary of euro3638.00 on the basis of full-time employment. This is a temporaryappointment for 4 year. The terms of employment are in accordance withthe CAO Dutch UMC's. We can help you find housing and child daycarefacilities in the area.
Requirements:
We seek highly motivated candidates with a PhD degree in Biology,Biomedical Sciences or Molecular Biology, with an excellent track recordand an interest in research focused on fundamental and clinical aspectsof oncogenesis in a unique multidisciplinary setting. Expertise withlaboratory animals is preferred. You have excellent written and oralcommunication skills in English and a desire for a career in research.
Organization:
University Medical Center Utrecht (UMC Utrecht) is, with almost 10,000employees, one of the largest public health care institutions in theheart of the Netherlands. It offers a unique combination of patientcare, biomedical and healthcare research. Dutch UMC’s have great recordsin terms of quantity and quality of their international scientificpublications. UMC Utrecht ranked 42 of best 500 Universities world widein 2005 and seventh in Europe. At UMC Utrecht, one of our major goals isto translate results from our laboratory research into new diagnostictools and new therapies for disease.The Oncology program is one of themajor focus areas and houses the UMC Utrecht Cancer Centre, whichcoordinates a mouse clinic for preclinical drug testing. The Pathologydepartment is a rapidly growing unit committed to developing andapplying preclinical animal models for cancer, and evaluatingtranslating the findings in patient tissues for diagnosis making,imaging and therapeutic targeting. The department has access to the keyrequired facilities for ABI capillary sequencing, laser capture microdissection, confocal scanning, real-time PCR, proteomics and cuttingedge immunohistochemistry.
About Utrecht:
Utrecht city is the capital and most populous city of the Dutch provinceof Utrecht. It is located in the Randstad, and is the fourth largestcity of the Netherlands, with a population of 280,000. Utrecht's ancientcity-center features many buildings and structures from its earliestorigins onwards. It's Roman origins date back to around the year 47 ce.Utrecht is host to Utrecht University, the largest university of theNetherlands, as well as several other institutes for higher education.Due to its central position within the country it is an importanttransportation hub (rail and road) in the Netherlands. It has the secondhighest number of cultural events in the Netherlands, after Amsterdam (http://www.utrecht.nl/).
Contact
Marc Vooijs
Pathology, room H04.312
University Medical Center Utrecht
Heidelberglaan 100
Utrecht, Utrecht 3584 CX
Netherlands
Phone: +31-30-2508316
Fax: +31-30-2544990
Email: m.vooijs@umcutrecht.nl
Employer's Web Site: http://www.umcutrecht.nl
University Medical Center Utrecht
Position
Postdoc position in cancer biology at University Medical Center Utrecht,The Netherlands
Job Number
4002383
Date Posted
Nov 22th 2007
Application Deadline
Open Until Filled
Description
Project description:
Metastases formation is a major factor in disease progression andaccounts for the majority of cancer deaths. The molecular mechanismscontrolling invasion, dissemination to blood or lymphatic systems andtumor spread of tumor cells to distant organs are still poorlyunderstood. Recent observations indicate that the metastatic phenotypemay already be present during the angiogenic switch of tumors. One ofcrucial rate-limiting events during human tumor growth is encounteredwhen tumors outgrow the pre-existing vasculature leading to hypoxia(oxygen insufficiency).
Intratumoral hypoxia is a hallmark of solid cancers. Hypoxic tumors havea higher tendency to metastasize and are clinically characterized bytherapy resistance and a poor prognosis. The Hypoxia Inducible Factors(HIF) are key molecules in the hypoxic response and play critical rolesduring tumor cell expansion by regulating energy metabolism and theinduction of angiogenesis. Our lab recently identified TWIST1: anoncogene involved in resistance to apoptosis and inducer ofepithelial-to-mesenchymal transition as a key target of HIF.
This main topics of this project are.
1. Further characterization of the role of TWIST1 in hypoxia response invitro and in vivo
2. Clonal analysis (Molecular imaging) of hypoxic tumor cells in vivo.
3. Development of therapeutic antibodies to eliminate hypoxic tumor cellin vivo.
Terms and conditions:
A postdoctoral position with a maximum gross monthly salary of euro3638.00 on the basis of full-time employment. This is a temporaryappointment for 4 year. The terms of employment are in accordance withthe CAO Dutch UMC's. We can help you find housing and child daycarefacilities in the area.
Requirements:
We seek highly motivated candidates with a PhD degree in Biology,Biomedical Sciences or Molecular Biology, with an excellent track recordand an interest in research focused on fundamental and clinical aspectsof oncogenesis in a unique multidisciplinary setting. Expertise withlaboratory animals is preferred. You have excellent written and oralcommunication skills in English and a desire for a career in research.
Organization:
University Medical Center Utrecht (UMC Utrecht) is, with almost 10,000employees, one of the largest public health care institutions in theheart of the Netherlands. It offers a unique combination of patientcare, biomedical and healthcare research. Dutch UMC’s have great recordsin terms of quantity and quality of their international scientificpublications. UMC Utrecht ranked 42 of best 500 Universities world widein 2005 and seventh in Europe. At UMC Utrecht, one of our major goals isto translate results from our laboratory research into new diagnostictools and new therapies for disease.The Oncology program is one of themajor focus areas and houses the UMC Utrecht Cancer Centre, whichcoordinates a mouse clinic for preclinical drug testing. The Pathologydepartment is a rapidly growing unit committed to developing andapplying preclinical animal models for cancer, and evaluatingtranslating the findings in patient tissues for diagnosis making,imaging and therapeutic targeting. The department has access to the keyrequired facilities for ABI capillary sequencing, laser capture microdissection, confocal scanning, real-time PCR, proteomics and cuttingedge immunohistochemistry.
About Utrecht:
Utrecht city is the capital and most populous city of the Dutch provinceof Utrecht. It is located in the Randstad, and is the fourth largestcity of the Netherlands, with a population of 280,000. Utrecht's ancientcity-center features many buildings and structures from its earliestorigins onwards. It's Roman origins date back to around the year 47 ce.Utrecht is host to Utrecht University, the largest university of theNetherlands, as well as several other institutes for higher education.Due to its central position within the country it is an importanttransportation hub (rail and road) in the Netherlands. It has the secondhighest number of cultural events in the Netherlands, after Amsterdam (http://www.utrecht.nl/).
Contact
Marc Vooijs
Pathology, room H04.312
University Medical Center Utrecht
Heidelberglaan 100
Utrecht, Utrecht 3584 CX
Netherlands
Phone: +31-30-2508316
Fax: +31-30-2544990
Email: m.vooijs@umcutrecht.nl
Employer's Web Site: http://www.umcutrecht.nl
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