Institution
University of Birmingham
Position
Postdoc in NMR spectroscopy in Cancer Metabolomics
Location
Birmingham, UK
Date Posted
Nov 30th 2007
Description
Background
A postdoctoral position funded by a Marie Curie project (MOTET) is available within an active and highly
interdisciplinary cancer metabolomics research program. The position will be jointly supervised by Mark Viant
(School of Biosciences), Chris Bunce (School of Biosciences) and Ulrich Günther (Cancer Studies). The position will
initially be funded for 2 years, with extension dependant upon successful acquisition of continued funding. A close
collaboration between the new Henry Wellcome Building for Biomolecular NMR Spectroscopy (HWB•NMR) at Birmingham.
The focus of the research will be NMR based metabolomics in a cancer context including the analysis of cellular
models, tissue samples and body fluids.
Duties
The focus of this position will be the preparation of metabolite and protein samples from cultured cells and their
analysis using current and developing NMR approaches. Target cells will include cell lines representative human
leukaemias, prostate cancer and neuroblastoma. Aldoketoreductase-1C3 activity in these cells will be manipulated
using transgenic approaches to either elevate or knock down expression and following exposure to non-steroidal and
steroidal inhibitors. Work in this context will also include the development and implementation of new NMR
techniques including fast methods to record multi-dimensional spectra, dynamic nuclear polarisation (DNP)
experiments and software for data evaluation.
Qualifications
Applications are invited from experienced researchers who have already obtained a doctoral degree or who have
worked in their field of expertise for at least 4 years after graduation from university. Applicants should either
have a background in biochemistry or biology, some experience in NMR spectroscopy or software development will be
beneficial.
Additional Notes
The HWB•NMR provides an excellent environment for research in the areas of biomolecular NMR spectroscopy and
metabolomics. The NMR centre houses several newly installed spectrometers from 500 to 900 MHz with various
cryogenically cooled probes and automated sample changers.
In addition, the HWB•NMR has been established as Varian Inc.’s European test site for NMR metabolomics research,
and as a BBSRC-funded European High Throughput NMR Centre for Metabolomics and Ligand Discovery. The laboratories
for cell culture work in the School of Biosciences have been newly refurnished, and a fully equipped laboratory for
production of recombinant proteins is also available.
Transnational mobility regulations apply for this position, i.e. researchers must not have resided in the UK for
the past 12 months and should be EU residents.
Contact
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