英国诺丁汉大学药学院干细胞研究博士后岗位
日期：2008-01-11
来源：丁香人才网
InstitutionThe University of Nottingham (http://www.nottingham.ac.uk)PositionPostdoctoral Research FellowLocationNottingham UKDate PostedJan 10th 2008Date ExpiresJan 25th 2008Salary £25134 per a ...
Institution
The University of Nottingham (http://www.nottingham.ac.uk)
Position
Postdoctoral Research Fellow
Location
Nottingham, UK
Date Posted
Jan 10th 2008
Date Expires
Jan 25th 2008
Salary
£25,134 per annum.
Description
School of Pharmacy
Postdoctoral Research Fellow
Optimised isolation, characterisation and osteogenic induction ofmesenchymal stem cells from umbilical cord blood: comparison with bonemarrow mesenchymal and embryonic stem cells
Applications are invited for the above post to work on an EU FrameworkVI-funded working with Dr Lee Buttery in the Division of Drug Deliveryand Tissue Engineering. This project is part of a large multi-centre,multidisciplinary project to optimise the isolation and expansion ofmesenchymal stem cells from human umbilical cord blood. The pluripotencyof these cells will be examined, but lineage-specific differentiationwill be focused on osteogenesis. The cells will be characterised bygenomic, proteomic and bioimpedance profiling, pre- and post-osteogenicdifferentiation. A key part of the project will be comparison of cordblood mesenchymal stem cells with mesenchymal isolated from human bonemarrow and also embryonic stem cells. The work at Nottingham will focuson the osteogenic differentiation of human ES cells.
Full bioinformatics integration of datasets will allow us to identifyspecific and/or novel signalling factors associated with these stemcells. Comparative analyses of the population doubling times, telomerelength and telomerase activity will identify the longevity of the stemcells. Novel expansion techniques will be combined with scale-upprocedures and the generation of cord blood mesenchymal stem cell linesfor banking using optimised cryopreservation protocols. In vitro and invivo biocompatibility assays using a range of biomimetic scaffolds willbe exploited, complementing in vivo homing, engraftment and bone repair models.
Our integrated approach using existing and complementary expertise willprovide a timely and thorough evaluation of cord blood mesenchymal stemcells and define appropriate routes for their therapeutic implementation.
Candidates must hold a PhD in a relevant subject and be highly motivatedscientists with interests in stem cell biology and routes to controllingtheir differentiation and therapeutic applications. The project uses avariety of cell biology, molecular biology and biochemical techniques.Experience in ES cell culture is desirable, but training can be provided.
This post offers an excellent opportunity to carry out research in athriving scientific environment and to interact with a largemultidisciplinary consortium of cell biologists, tissue engineers andmaterials scientists.
This post is available immediately and will be offered on a fixed-termcontract for a period of one year.
Contact
Informal enquiries may be addressed to Dr L Buttery, tel: 0115 846 7857or Email: Lee.Buttery@Nottingham.ac.uk.
Candidates should send a detailed CV, together with the names andaddresses of two referees, to Dr L Buttery, School of Pharmacy, BootsScience Building, The University of Nottingham, University Park,Nottingham, NG7 2RD. Please quote ref. SCI/356. Closing date: 25 January 2008.
The University of Nottingham (http://www.nottingham.ac.uk)
Position
Postdoctoral Research Fellow
Location
Nottingham, UK
Date Posted
Jan 10th 2008
Date Expires
Jan 25th 2008
Salary
£25,134 per annum.
Description
School of Pharmacy
Postdoctoral Research Fellow
Optimised isolation, characterisation and osteogenic induction ofmesenchymal stem cells from umbilical cord blood: comparison with bonemarrow mesenchymal and embryonic stem cells
Applications are invited for the above post to work on an EU FrameworkVI-funded working with Dr Lee Buttery in the Division of Drug Deliveryand Tissue Engineering. This project is part of a large multi-centre,multidisciplinary project to optimise the isolation and expansion ofmesenchymal stem cells from human umbilical cord blood. The pluripotencyof these cells will be examined, but lineage-specific differentiationwill be focused on osteogenesis. The cells will be characterised bygenomic, proteomic and bioimpedance profiling, pre- and post-osteogenicdifferentiation. A key part of the project will be comparison of cordblood mesenchymal stem cells with mesenchymal isolated from human bonemarrow and also embryonic stem cells. The work at Nottingham will focuson the osteogenic differentiation of human ES cells.
Full bioinformatics integration of datasets will allow us to identifyspecific and/or novel signalling factors associated with these stemcells. Comparative analyses of the population doubling times, telomerelength and telomerase activity will identify the longevity of the stemcells. Novel expansion techniques will be combined with scale-upprocedures and the generation of cord blood mesenchymal stem cell linesfor banking using optimised cryopreservation protocols. In vitro and invivo biocompatibility assays using a range of biomimetic scaffolds willbe exploited, complementing in vivo homing, engraftment and bone repair models.
Our integrated approach using existing and complementary expertise willprovide a timely and thorough evaluation of cord blood mesenchymal stemcells and define appropriate routes for their therapeutic implementation.
Candidates must hold a PhD in a relevant subject and be highly motivatedscientists with interests in stem cell biology and routes to controllingtheir differentiation and therapeutic applications. The project uses avariety of cell biology, molecular biology and biochemical techniques.Experience in ES cell culture is desirable, but training can be provided.
This post offers an excellent opportunity to carry out research in athriving scientific environment and to interact with a largemultidisciplinary consortium of cell biologists, tissue engineers andmaterials scientists.
This post is available immediately and will be offered on a fixed-termcontract for a period of one year.
Contact
Informal enquiries may be addressed to Dr L Buttery, tel: 0115 846 7857or Email: Lee.Buttery@Nottingham.ac.uk.
Candidates should send a detailed CV, together with the names andaddresses of two referees, to Dr L Buttery, School of Pharmacy, BootsScience Building, The University of Nottingham, University Park,Nottingham, NG7 2RD. Please quote ref. SCI/356. Closing date: 25 January 2008.
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