英国肿瘤研究院伦敦研究所博士后岗位

Institution

Cancer Research UK London Research Institute

Position

Postdoctoral Research Fellow

Location

South Mimms, UK within M25 borders

Date Posted

July 11th 2008

Date Expires

August 15th 2008

Tags

postdoctoral, biochemistry, yeast, genetics, dna, and cell cycle 

Description

Several 3-year post-doctoral fellowships are available in the laboratory of Dr John Diffley at Cancer Research UK’s London Research Institute, based in the Clare Hall Laboratories.

We are interested in understanding the mechanism and regulation of DNA replication. We study the process in budding yeast, mouse and human cells. We are interested in several questions:
What are the mechanisms involved in initiating DNA replication?
How is DNA replication regulated during the cell cycle?
How is DNA replication regulated in response to DNA damage?
Does the misregulation of DNA replication contribute to cancer genesis?

Candidates should have a strong background in either: biochemistry, yeast, genetics, mammalian cell culture or mouse models.

Publications:
Segurado and Diffley (2008) Genes & Development 22:1816-1827
Baxter and Diffley (2008) Molecular Cell 30:790-802
Zegerman and Diffley (2007) Nature 445:281-285
Mailand and Diffley (2005) Cell 122:915-926

Salary in the range of ￡25500 – ￡33000, plus location allowance of ￡2470, plus benefits.

Contact

Please submit a full cv and covering letter to john.diffley@cancer.org.uk by 15th August 2008.