美国辉瑞公司癌症遗传学博士后岗位

Cancer Genetics R5/R6 (Oncology) : La Jolla, CA

Institution

Pfizer Inc.

Position

Postdoctoral Position

Website

http://posttrak.arbita.net/cg

Location

La Jolla, CA

Date Posted

July 29, 2009

Date Expires

August 28, 2009  

Description

Apply a wide variety of –omics assay technologies to establish molecular characteristics of cancer tissues and cells under different conditions. Utilize these molecular characteristics to gain mechanistic insight leading to new targets and mechanisms for cancer therapy, new biomarkers for patient selection and response, and validation of targets. This position emphasizes cancer genetics expertise, but will integrate data from other omics approaches.

Primary Duties:

• Apply cancer genetic approaches within Target ID & Val group
• Acquire appropriate cancer cell and tissue samples, prep or generate extracts for analysis. This will include culturing various cancer cell lines under different treatment conditions, acquisition of tumor biopsies and in vivo models tissues via partnerships, LCM of samples to further dissect, prep of tissues/cells for in situ analyses
• Develop, validate, and apply various –omics assays, including genomic mutational analysis, genomic epigenetic analysis, transcriptional profiling, proteomics, phospho-proteomics, IHC, ISH. Partner with internal and external experts to support these activities
• Partnering with collaborators and computational biologists, mine internal and external databases to extract and integrate available, relevant –omics data
• Establish basal molecular profiles, then measure and evaluate changes in molecular profiles when cancer cells/tissues are perturbed/modulated by different stimuli, compound treatment, RNAi knock-down, combination treatments, and acquisition of resistance
• Partnering with computational biologists, conduct complex data analysis to decipher mechanism of action of perturbation/modulation leading to the generation of hypotheses for new targets and mechanisms for cancer therapy, integration of data from multiple approaches to generate target hypotheses
• Manage external Omics collaborations
• Contribute to strategy and tactics for Target ID & Val within Disease specialty group, and ensure technical interface across disease specialty groups
• Contribute to building a culture that embraces continuous learning and improvement, increasing technical skill base and disease biology expertise; take a proactive role in personal growth and scientific development

Qualifications:

Training & Education Preferred:
• PhD or MD/PhD in Cell Biology, Molecular Biology, Biochemistry (or a comparable biological science) with a cancer-related focus
• Deep knowledge of targets and pathways of importance to tumorigenesis and progression
• Expert in tissue and cell analysis, DNA and RNA assay technologies, protein immunoassay technologies
• Expert with data capture/analysis of large datasets
• Demonstrated proficiency in the use of software tools to support data analysis tasks (e.g., SIGHTS, Spotfire, protocol development and registration).
• Have a good understanding of the future of the cancer field in general

Prior Experience Preferred:

• At least 5 years experience working primarily on cancer biology, preferably in one or more of the tumor types covered in this Disease Specialty group
• At least 5 years experience (post degree) in industry or academic lab focused on –omics technologies
• Extensive expertise in cancer genetics and epigenetics
• Demonstrated ability to supervise direct reports
• Hands on, extensive experience with at least one of the –omics technologies mentioned above, with clear conceptual understanding of additional –omics technologies
• Able to work in a team environment; good communication skills; able to present data at project team meetings
• Ideally, the candidate will have demonstrated skills and success in networking and identifying and managing partnerships/collaborations

Throughout our 153 years, a legacy of caring for others has been at the heart of everything we do at Pfizer. This commitment is no less important when it comes to our employees. Pfizer wants to ensure that employees have resources to help them develop and succeed both in their careers and personal lives. One way we can achieve this is through our comprehensive benefits program, which offers employees and their eligible dependents the variety and flexibility to help address their needs at different stages in life.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act.

All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S.

For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague’s long-term prospects for securing lawful permanent residence, among other reasons.

Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer’s support of a colleague’s temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the “at-will” employment relationship between the colleague and Pfizer.

Contact

To apply for this position please go to:
http://posttrak.arbita.net/cgi-bin/PostTrak.cgi?RefCode=R9196213907653

来源：http://www.nature.com/naturejobs/science/jobs/105724-Cancer-Genetics-R5-R6-Oncology