剑桥大学生殖免疫研究博士后研究助理

Post-Doctoral Research Associate : Cambridge, CB2 1QP, UK

Employer:

University of Cambridge

Website:

http://www.cam.ac.uk

Location:

Cambridge, CB2 1QP, UK

Posted:

December 02, 2009

Expires:

January 10, 2010

Jobs by tag(s):

pathology, Reproductive Immunobiology , cell biology, immunogenetics, Cambridge, postdoc, research associate 

Requisition number:

PK06032

job description:

Post-Doctoral Research Associate

Department of Pathology

Vacancy Reference No: PK06032 Salary: £27,183-£35,469

Limit of tenure applies‡

Project title: Immunogenetics of killer cell immunoglobulin-like receptors (KIR) and HLA-C in pre-eclampsia

We are seeking a post-doctoral Research Associate to join the Division of Immunology in the Reproductive Immunobiology group headed by Professor Ashley Moffett. The group comprises eight scientists working on the role of the maternal immune system in regulating placental development and function. This project, funded by the British Heart Foundation, extends our work on how the maternal uterine immune system, especially the Natural Killer (NK) cells, regulates placentation through recognition of MHC Class I ligands on the invading fetal trophoblast cells (Moffett and Loke, Nat Rev Immunol 2006; Hiby et al J Exp Med 2004; Hum Reprod 2008 – www.path.cam.ac.uk/research/investigators/moffett/research). We have already found that certain maternal KIR/fetal HLA-C combinations are associated with diseases of pregnancy such as pre-eclampsia and recurrent miscarriage.

This is a combined study using immunogenetics of pathological pregnancies and cell biology to define the outcome of different KIR/HLA ligand interactions. The post holder will work closely with other members of the group and with our outside collaborators. Familiarity with PCR techniques that are used for genotyping and with some statistical knowledge will be useful. Cell culture experiments and FACS analysis with fusion proteins will also be used to study maternal allorecognition of fetal MHC proteins. Training will be given as required.

The maximum starting salary for this position will be £27,183.

contact:

For an application form (PA23), please email jobs@path.cam.ac.uk or telephone (01223) 333690. The PA23 and a copy of your CV should be either emailed to: jobs@path.cam.ac.uk or posted to: Reception, Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP. Please quote the job reference number on all correspondence.

‡ Limit of tenure:

The funds for this position are available for 3 years.Closing date: 10 January 2010.

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