We are looking for an enthusiastic, dynamic and highly motivated applicant to join our lab, which employs a multi-disciplinary approach to investigating several fundamental features of muscle contraction: the structure-function relationships among amino acid residues of actin, tropomyosin, and myosin; the mechanisms that underlie hypertrophic and dilative cardiomyopathies (HCM, DCM); and the molecular mechanisms that are responsible for force generation. Our lab has established a thin filament reconstitution system and employs this to study contractility in skinned myocardium (cardiac muscle fibers), in particular, to detect force, stiffness, force transients, and kinetic constants of the cross-bridge cycle. The College of Medicine at The University of Iowa offers excellent central core research facilities (http://www.healthcare.uiowa.edu/corefacilities/), including Electron Microscopy & Imaging and Bioengineering facilities, as well as an excellent Medical Instrument Shop—all of which greatly facilitate our work. Preference will be given to recent PhDs or MD/PhDs who have experience carrying out studies in skinned fibers, protein purification, and/or studies on molecular motors. Excellence and independence will be the most important criteria in selecting the successful candidate. For additional information on research in Kawai’s lab, please see the following publications:
J Muscle Res Cell Motil 27: 455-468 (2006)
Biophys J 100: 1014-1023 (2011)
PLoS ONE 7: (e4741) 1-12 (2012)
Journal of Molecular and Cellular Cardiology 62:153-163 (2013)
J Muscle Res Cell Motil 34: 295-310 (2013)
Biophys J. 106:1112-1122 (2014)
and/or our website (http://www.medicine.uiowa.edu/dept_primary_apr.aspx?appointment=Anatomy%20and%20Cell%20Biology&id=kawaim).
A survey of postdoctoral students by The Scientist magazine ranks the University of Iowa as the top research university for postdocs in North America and the fifth-best research institution overall (http://www.news-releases.uiowa.edu/2007/March/030107post-doctorate.html). Iowa City is consistently voted one of the most livable cities in the US: the cost of living is one of the lowest, and Iowa City and the University offer a wide array of cultural and sport events including theatrical and musical performances, art exhibitions, and big 10 athletic meets.
Applicants should send a curriculum vitae and a description of research experience and interests, along with the names and contact information of three references, to . The University of Iowa is an Affirmative Action / Equal Employment Opportunity Employer.