Aachen大学肿瘤研究博士后

Postdoc position: Inflammatory signaling pathways in liver cancer : Aachen, Germany

Employers:

University of Aachen (RWTH), Medical Faculty 

Location(s):

Aachen, Germany

Posted:

September 15, 2010

Expires:

December 14, 2010

Job Tag(s):

postdoc,aachen,germany,cell biology,immunology,genetics,knockout mouse

Description:

The Project
Our ERC-funded research group is studying cell biological and immunological aspects of liver cancer development. A special focus is the role of cytokines and inflammatory signalling pathways in mediating the transition from chronic inflammation to the malignant transformation of cells. In the respective project the role of a newly defined molecule that supposedly integrates inflammatory and developmental signals will be analysed in a genetic model of liver cancer.

This work includes the characterization of a newly generated mouse model (conditional gene targeting approach), primary cell culture-work, innovative biological and immunological techniques including protein biochemistry, expression analysis (protein, RNA, immunohistochemistry), FACS analysis, adoptive cell transfers, molecular biology, in vivo imaging by 2-photon-microscopy etc. Moreover results will be transferred into patient material from a big tissue bank.

For relevant literature see:

Bettermann K, /… and Luedde T. TAK1 suppresses a NEMO-dependent, but NF-kappaB-independent pathway to liver cancer. Cancer Cell 2010; May; 18;17(5):481-96.

Luedde T, et al.: Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell. 2007 Feb;11(2):119-32.

Qualifications
We are looking for a talented and highly motivated candidate with an excellent education and enthusiasm for basic research work with relevance for human disease, especially cancer. Prerequisite for a successful application is a Ph.D. or Dr. rer. nat. in the fields of biology, biochemistry, biotechnology, chemistry, pharmacy, medicine or similar. Obtained experience with mouse as model organism is an absolute prerequisite, good cloning skills would be appreciated but are not necessarily required. The publication record should reflect the candidate’s ability to pursue a project successfully.

Job details and application
We offer an innovative research project in an international, dynamic and highly interdisciplinary research environment with excellently equipped facilities. We are maintaining a close collaboration and regular exchange of scientists with laboratories in Europe (Zürich, Munich, Newcastle, Leuven) and the U.S. (New York). The position is available from 11/2010 on or later, salary is paid according to the German TVL system.

The University of Aachen is an employer committed to equal opportunities. Female applicants are strongly encouraged to apply to this position. Applicants with handicap or from minorities which are equally qualified will be preferentially selected.

Contact:

Please send application material, including a cover letter, CV, publication list, and names and contact details of three references to:

Please send your application including a cover letter, CV, publication list and contact details of at least one reference preferentially per email with one single PDF file-attachment to:

PD Dr. Tom Luedde, M.D./Ph.D.
Department of Medicine 3
University Hospital RWTH Aachem
Pauwelsstrasse 30
D-52074 Aachen
Germany
Email: research.aachen@yahoo.com