钱浩
教授
长期从事神经系统相关研究，致力于将基础科研与临床应用结合起来，利用解决神经科学基本问题过程中所获得的重要成果指导针对神经系统疾病治疗新策略的开发。在加州大学圣迭戈分校工作期间，与其他同事共同阐明了神经元转分化的关键性调控通路，开发了将人源成纤维细胞高效重编程为神经元的方法。在此基础上，进一步建立起诱导星形胶质细胞转分化为神经元的技术路线。这一方法能在哺乳动物大脑中直接产生新生神经元，并重建被破坏的神经通路，改善帕金森症动物的症状。为研发治疗一系列神经退行性疾病的临床策略提供了新的思路。
科研项目：
1，星形胶质细胞向神经元转分化的机制 2，RNA 转录后加工与神经系统疾病的发生 3，神经系统疾病新治疗方法的开发
研究成果：
1.Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, FanMeng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Zhuan Zhou, Neal K. Devaraj,Steven F. Dowdy, William C. Mobley, Don W. Cleveland, Xiang-Dong FuReversing Parkinson Disease Model with in situ Converted Nigral NeuronsNature, 2020; 582 (7813): 550-556 2.Yuanchao Xue*, Hao Qian*, Jing Hu,Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-DongFu Sequential regulatory loops as key gatekeepers for neuronalreprogramming in human cells Nature neuroscience, 2016; 19(6): 807–815.3.Bo Wen*, Hao Qian*, Jing Feng, Rong‐Jing Ge, Xin Xu, Zhi‐Qiang Cui,Ru‐Yuan Zhu, Long‐Sheng Pan, Zhi‐Pei Lin, Jin‐Hui Wang A portion ofinhibitory neurons in human temporal lobe epilepsy are functionallyupregulated: an endogenous mechanism for seizure termination CNSneuroscience & therapeutics, 2014; 21 (2): 204-214. 4.Jiandong Yu*,Hao Qian*, Na Chen, JH Wang Quantal glutamate release is essential forreliable neuronal encodings in cerebral networks PLoS One, 2011; 6(9):e25219 5.Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu PTB/nPTB: masterregulators of neuronal fate in mammals Biophysics reports, 2018; 4 (4):204–214 6.Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Ying Gu, Jinsong Qiu,Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, YuZhou, Omar Abdel-Wahab, Dong-Er Zhang, Xiang-Dong Fu The AugmentedR-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced byHigh-Risk Splicing Factor Mutations Molecular cell, 2018; 69(3):412–425. 7.Liang Chen, Jia-Yu Chen, Xuan Zhang, Ying Gu, Rui Xiao,Changwei Shao, Peng Tang, Hao Qian, Daji Luo, Hairi Li, Yu Zhou, Dong-ErZhang, Xiang-Dong Fu R-ChIP Using Inactive RNase H Reveals DynamicCoupling of R-loops with Transcriptional Pausing at Gene PromotersMolecular cell, 2017; 68(4): 745–757. 8.Zhen-Ning Zhang, Beatriz CFreitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A Trujillo, Roberto HHerai, Viet Anh Nguyen Huu, Jessica H Wen, Shivanjali Joshi-Barr, JeromeV Karpiak, Adam J Engler, Xiang-Dong Fu, Alysson R Muotri, AdahAlmutairi Layered hydrogels accelerate iPSC-derived neuronal maturationand reveal migration defects caused by MeCP2 dysfunction Proceedings ofthe National Academy of Sciences, 2016; 113(12): 3185–3190 9.RongjingGe, Hao Qian, Na Chen, Jin-Hui Wang Input-dependent subcellularlocalization of spike initiation between soma and axon at corticalpyramidal neurons Molecular Brain, 2014; 7(26) 10.Jiandong Yu, Hao Qian,JH Wang Upregulation of transmitter release probability improves aconversion of synaptic analogue signals into neuronal digital spikesMolecular Brain, 2012; 5(26) 11.Haiyun Tang, Hongyu Long, Chang Zeng, YiLi, Fangfang Bi, Jinhui Wang, Hao Qian, Bo Xiao Rapamycin suppresses therecurrent excitatory circuits of dentate gyrus in a mouse model oftemporal lobe epilepsy Biochemical and Biophysical ResearchCommunications, 2012; 420(1): 199–204 12.Rongjing Ge, Hao Qian, Jin-HuiWang Physiological synaptic signals initiate sequential spikes at somaof cortical pyramidal neurons Molecular Brain, 2011; 4(19) 13.Na Chen,Jiandong Yu, Hao Qian, Rongjing Ge, Jin-Hui Wang Axons Amplify SomaticIncomplete Spikes into Uniform Amplitudes in Mouse Cortical PyramidalNeurons PLoS One. 2010; 5(7): e11868
长期从事神经系统相关研究，致力于将基础科研与临床应用结合起来，利用解决神经科学基本问题过程中所获得的重要成果指导针对神经系统疾病治疗新策略的开发。在加州大学圣迭戈分校工作期间，与其他同事共同阐明了神经元转分化的关键性调控通路，开发了将人源成纤维细胞高效重编程为神经元的方法。在此基础上，进一步建立起诱导星形胶质细胞转分化为神经元的技术路线。这一方法能在哺乳动物大脑中直接产生新生神经元，并重建被破坏的神经通路，改善帕金森症动物的症状。为研发治疗一系列神经退行性疾病的临床策略提供了新的思路。
科研项目：
1，星形胶质细胞向神经元转分化的机制 2，RNA 转录后加工与神经系统疾病的发生 3，神经系统疾病新治疗方法的开发
研究成果：
1.Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, FanMeng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Zhuan Zhou, Neal K. Devaraj,Steven F. Dowdy, William C. Mobley, Don W. Cleveland, Xiang-Dong FuReversing Parkinson Disease Model with in situ Converted Nigral NeuronsNature, 2020; 582 (7813): 550-556 2.Yuanchao Xue*, Hao Qian*, Jing Hu,Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-DongFu Sequential regulatory loops as key gatekeepers for neuronalreprogramming in human cells Nature neuroscience, 2016; 19(6): 807–815.3.Bo Wen*, Hao Qian*, Jing Feng, Rong‐Jing Ge, Xin Xu, Zhi‐Qiang Cui,Ru‐Yuan Zhu, Long‐Sheng Pan, Zhi‐Pei Lin, Jin‐Hui Wang A portion ofinhibitory neurons in human temporal lobe epilepsy are functionallyupregulated: an endogenous mechanism for seizure termination CNSneuroscience & therapeutics, 2014; 21 (2): 204-214. 4.Jiandong Yu*,Hao Qian*, Na Chen, JH Wang Quantal glutamate release is essential forreliable neuronal encodings in cerebral networks PLoS One, 2011; 6(9):e25219 5.Jing Hu, Hao Qian, Yuanchao Xue, Xiang-Dong Fu PTB/nPTB: masterregulators of neuronal fate in mammals Biophysics reports, 2018; 4 (4):204–214 6.Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Ying Gu, Jinsong Qiu,Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, YuZhou, Omar Abdel-Wahab, Dong-Er Zhang, Xiang-Dong Fu The AugmentedR-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced byHigh-Risk Splicing Factor Mutations Molecular cell, 2018; 69(3):412–425. 7.Liang Chen, Jia-Yu Chen, Xuan Zhang, Ying Gu, Rui Xiao,Changwei Shao, Peng Tang, Hao Qian, Daji Luo, Hairi Li, Yu Zhou, Dong-ErZhang, Xiang-Dong Fu R-ChIP Using Inactive RNase H Reveals DynamicCoupling of R-loops with Transcriptional Pausing at Gene PromotersMolecular cell, 2017; 68(4): 745–757. 8.Zhen-Ning Zhang, Beatriz CFreitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A Trujillo, Roberto HHerai, Viet Anh Nguyen Huu, Jessica H Wen, Shivanjali Joshi-Barr, JeromeV Karpiak, Adam J Engler, Xiang-Dong Fu, Alysson R Muotri, AdahAlmutairi Layered hydrogels accelerate iPSC-derived neuronal maturationand reveal migration defects caused by MeCP2 dysfunction Proceedings ofthe National Academy of Sciences, 2016; 113(12): 3185–3190 9.RongjingGe, Hao Qian, Na Chen, Jin-Hui Wang Input-dependent subcellularlocalization of spike initiation between soma and axon at corticalpyramidal neurons Molecular Brain, 2014; 7(26) 10.Jiandong Yu, Hao Qian,JH Wang Upregulation of transmitter release probability improves aconversion of synaptic analogue signals into neuronal digital spikesMolecular Brain, 2012; 5(26) 11.Haiyun Tang, Hongyu Long, Chang Zeng, YiLi, Fangfang Bi, Jinhui Wang, Hao Qian, Bo Xiao Rapamycin suppresses therecurrent excitatory circuits of dentate gyrus in a mouse model oftemporal lobe epilepsy Biochemical and Biophysical ResearchCommunications, 2012; 420(1): 199–204 12.Rongjing Ge, Hao Qian, Jin-HuiWang Physiological synaptic signals initiate sequential spikes at somaof cortical pyramidal neurons Molecular Brain, 2011; 4(19) 13.Na Chen,Jiandong Yu, Hao Qian, Rongjing Ge, Jin-Hui Wang Axons Amplify SomaticIncomplete Spikes into Uniform Amplitudes in Mouse Cortical PyramidalNeurons PLoS One. 2010; 5(7): e11868