张新军
教授，博士生导师
国家级青年人才，四川省领军人才。电子科技大学医学院和四川省医学科学院·四川省人民医院遗传中心教授。主要从事 Wnt通路和细胞内囊泡运输调控机制以及相关的疾病和转化研究。相关工作以第一作者或通讯作者发表于 Cell, Dev Cell, Mol Cell,Autophagy, EMBO R, JBC 等学术期刊。2015 年入选国家海外高层次人才引进计划青年项目（优先资助）。
科研项目：
1）电子科技大学高层次人才引进项目和四川省人民医院引进人才启动项目； 2）自然科学基金面上项目，2019-2022，57 万，主持；3）国家海外高层次人才引进计划青年项目，优先资助，2017-2020，300 万，主持。
研究成果：
代表性论文 1. Li M, Zheng J, Luo D, Xu K, Sheng R, MacDonald BT, He X, ZhangX. Frizzled receptors facilitate Tiki inhibition of Wnt signaling at thecell surface. EMBO Rep. 2023 Jun 5;24(6):e55873. doi:10.15252/embr.202255873. 2. Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, TanJ, Zhang X. Rab21 controls autophagy and cellular energy homeostasis byregulating retromer-mediated recycling of GLUT1. Autophagy. 2023Apr;19(4):1070-1086. doi: 10.1080/15548627.2022.2114271. 3. Zheng S, LinJ, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X,Zhao C, Qi J, Cao L, Wang M, He X, Sheng R. Aberrant CholesterolMetabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 inSupporting Cancer Growth. Adv Sci (Weinh). 2022 Oct;9(28):e2200750. doi:10.1002/advs.202200750. 4. Choi RB, Bullock WA, Hoggatt AM, Horan DJ,Pemberton EZ, Hong JM, Zhang X, He X, Robling AG. Notum Deletion FromLate-Stage Skeletal Cells Increases Cortical Bone Formation andPotentiates Skeletal Effects of Sclerostin Inhibition. J Bone Miner Res.2021 Dec;36(12):2413-2425. doi: 10.1002/jbmr.4411. 5. Li M, Zheng J, LuoD, Xu K, Zhang X. Tiki Proteins are Substrates of Membrane-type MatrixMetalloproteinases. FEBS Lett. 2022 Jul; 596(14):1851-1859. doi:10.1002/1873-3468.14423. 6. Li M, Zheng J, He X, Zhang X. Tiki proteinsare glycosylphosphatidylinositol-anchored proteases. FEBS Lett. 2022Apr; 596(8):1037-1046. doi: 10.1002/1873-3468.14320. 7. Zhang X, He X.Methods for Studying Wnt Protein Modifications/Inactivations byExtracellular Enzymes, Tiki and Notum. Methods Mol Biol. 2016; 1481:29-38. 8. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R,Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL,Dong M. Frizzled proteins are colonic epithelial receptors for C.difficile toxin B. Nature. 2016 Oct 20;538(7625):350-355. doi:10.1038/nature19799. 9. Zhang X, Macdonald BT, Gao H, Shamashkin M,Coyle AJ, Martinez RV, He X. Characterization of Tiki, a New Family ofWnt-specific Metalloproteases. J Biol Chem. 2016 Jan 29; 291(5):2435-43. 10. Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT,Zebisch M, Jones EY, Abreu JG, Xi He. Notum is required for neural andhead induction via Wnt deacylation, oxidation and inactivation. DevCell. 2015 Mar 23; 32(6): 719-30. 11. Zhang X, He X. PAF makes it EZ(H2)for β-catenin transactivation. Mol Cell. 2013 Oct 24; 52(2):157-8. 12.Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT,Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of β-cateninreveals principles for morphogen receptor-scaffold assemblies. Science.2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389. 13. Zhang X,Abreu JG, Yokota C, Macdonald BT, Singh S, Coburn KL, Cheong SM, ZhangMM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formationvia Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22; 149(7):1565-77. 14. Semenov MV, Zhang X, He X. DKK1 antagonizes Wnt signalingwithout promotion of LRP6 internalization and degradation. J Biol Chem.2008 Aug 1; 283(31):21427-32. 15. Zeng X, Huang H, Tamai K, Zhang X,Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J,Wynshaw-Boris A, Hsieh JC, He X. Initiation of Wnt signaling: control ofWnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelledand axin functions. Development. 2008 Jan; 135(2):367-75. 16. Zhang X,He X, Fu XY, Chang Z. Varp is a Rab21 guanine nucleotide exchange factorand regulates endosome dynamics. J Cell Sci. 2006 Mar 15; 119(Pt6):1053-62. 17. Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, HeX. A mechanism for Wnt coreceptor activation. Mol Cell. 2004 Jan 16; 13(1):149-56.
国家级青年人才，四川省领军人才。电子科技大学医学院和四川省医学科学院·四川省人民医院遗传中心教授。主要从事 Wnt通路和细胞内囊泡运输调控机制以及相关的疾病和转化研究。相关工作以第一作者或通讯作者发表于 Cell, Dev Cell, Mol Cell,Autophagy, EMBO R, JBC 等学术期刊。2015 年入选国家海外高层次人才引进计划青年项目（优先资助）。
科研项目：
1）电子科技大学高层次人才引进项目和四川省人民医院引进人才启动项目； 2）自然科学基金面上项目，2019-2022，57 万，主持；3）国家海外高层次人才引进计划青年项目，优先资助，2017-2020，300 万，主持。
研究成果：
代表性论文 1. Li M, Zheng J, Luo D, Xu K, Sheng R, MacDonald BT, He X, ZhangX. Frizzled receptors facilitate Tiki inhibition of Wnt signaling at thecell surface. EMBO Rep. 2023 Jun 5;24(6):e55873. doi:10.15252/embr.202255873. 2. Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, TanJ, Zhang X. Rab21 controls autophagy and cellular energy homeostasis byregulating retromer-mediated recycling of GLUT1. Autophagy. 2023Apr;19(4):1070-1086. doi: 10.1080/15548627.2022.2114271. 3. Zheng S, LinJ, Pang Z, Zhang H, Wang Y, Ma L, Zhang H, Zhang X, Chen M, Zhang X,Zhao C, Qi J, Cao L, Wang M, He X, Sheng R. Aberrant CholesterolMetabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 inSupporting Cancer Growth. Adv Sci (Weinh). 2022 Oct;9(28):e2200750. doi:10.1002/advs.202200750. 4. Choi RB, Bullock WA, Hoggatt AM, Horan DJ,Pemberton EZ, Hong JM, Zhang X, He X, Robling AG. Notum Deletion FromLate-Stage Skeletal Cells Increases Cortical Bone Formation andPotentiates Skeletal Effects of Sclerostin Inhibition. J Bone Miner Res.2021 Dec;36(12):2413-2425. doi: 10.1002/jbmr.4411. 5. Li M, Zheng J, LuoD, Xu K, Zhang X. Tiki Proteins are Substrates of Membrane-type MatrixMetalloproteinases. FEBS Lett. 2022 Jul; 596(14):1851-1859. doi:10.1002/1873-3468.14423. 6. Li M, Zheng J, He X, Zhang X. Tiki proteinsare glycosylphosphatidylinositol-anchored proteases. FEBS Lett. 2022Apr; 596(8):1037-1046. doi: 10.1002/1873-3468.14320. 7. Zhang X, He X.Methods for Studying Wnt Protein Modifications/Inactivations byExtracellular Enzymes, Tiki and Notum. Methods Mol Biol. 2016; 1481:29-38. 8. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R,Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL,Dong M. Frizzled proteins are colonic epithelial receptors for C.difficile toxin B. Nature. 2016 Oct 20;538(7625):350-355. doi:10.1038/nature19799. 9. Zhang X, Macdonald BT, Gao H, Shamashkin M,Coyle AJ, Martinez RV, He X. Characterization of Tiki, a New Family ofWnt-specific Metalloproteases. J Biol Chem. 2016 Jan 29; 291(5):2435-43. 10. Zhang X, Cheong SM, Amado NG, Reis AH, MacDonald BT,Zebisch M, Jones EY, Abreu JG, Xi He. Notum is required for neural andhead induction via Wnt deacylation, oxidation and inactivation. DevCell. 2015 Mar 23; 32(6): 719-30. 11. Zhang X, He X. PAF makes it EZ(H2)for β-catenin transactivation. Mol Cell. 2013 Oct 24; 52(2):157-8. 12.Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT,Zhang X, Garcia Abreu J, Peng L, He X. Wnt stabilization of β-cateninreveals principles for morphogen receptor-scaffold assemblies. Science.2013 May 17;340(6134):867-70. doi: 10.1126/science.1232389. 13. Zhang X,Abreu JG, Yokota C, Macdonald BT, Singh S, Coburn KL, Cheong SM, ZhangMM, Ye QZ, Hang HC, Steen H, He X. Tiki1 is required for head formationvia Wnt cleavage-oxidation and inactivation. Cell. 2012 Jun 22; 149(7):1565-77. 14. Semenov MV, Zhang X, He X. DKK1 antagonizes Wnt signalingwithout promotion of LRP6 internalization and degradation. J Biol Chem.2008 Aug 1; 283(31):21427-32. 15. Zeng X, Huang H, Tamai K, Zhang X,Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J,Wynshaw-Boris A, Hsieh JC, He X. Initiation of Wnt signaling: control ofWnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelledand axin functions. Development. 2008 Jan; 135(2):367-75. 16. Zhang X,He X, Fu XY, Chang Z. Varp is a Rab21 guanine nucleotide exchange factorand regulates endosome dynamics. J Cell Sci. 2006 Mar 15; 119(Pt6):1053-62. 17. Tamai K, Zeng X, Liu C, Zhang X, Harada Y, Chang Z, HeX. A mechanism for Wnt coreceptor activation. Mol Cell. 2004 Jan 16; 13(1):149-56.