子宫血管生物学实验室 Professor Gendie E Lash established the Laboratory of Uterine VascularBiology in the Institute of Pediatrics, Guangzhou Women and Children'sMedical Center, Guangzhou, China in July 2015. Dr Gendie E Lash is aGuangzhou high-level foreign expert and was awarded Guangzhou MedicalKey Talent status in 2016 and National Foreign Expert Program in 2021and 2023 for her outstanding research contributions. She has published150 papers which are cited 5451 times, with an H-index of 41. Dr GendieE Lash graduated from The University of Otago in Dunedin, New Zealand,and worked at the University of Nottingham (UK), Queen's University(Canada) and Newcastle University (UK). Dr Gendie E Lash is a senioreditor for Molecular Reproduction and Development, associate editor(China) for Placenta, and deputy editor for Maternal-Fetal Medicine. Sheis the immediate past editor of Trophoblast Research (supplement toPlacenta), and currently serves on the Editorial Boards of Journal ofReproductive Immunology and Frontiers (Reproduction and ImmuneTolerance). She reviews for a wide range of journals and grant fundingbodies. Dr Gendie E Lash is well-known in the obstetrics and gynecologyfield, and has been invited to speak at many national and internationalacademic conferences. Dr Lash’s research focuses on the role ofplacental and uterine factors in the regulation of trophoblast invasionand spiral artery remodeling, and key maternal adaptations to pregnancyand determining the pathophysiologic mechanism of the pregnancycomplications such as preeclampsia, fetal growth restriction andmiscarriage, with the ultimate goal to provide a theoretical basis forprevention and treatment of these disease and improve the reproductivewellbeing of women. More recently, members of Dr Lash’s laboratory havealso performed several successful studies on ovarian and endometrialcancer. The laboratory is funded by grants from the General Project ofNational Natural Science Foundation of China, Guangzhou Science andTechnology Project and Youth Science Foundation of National NaturalScience Foundation of China, etc. In addition, we were funded byFoundation and Application Foundation Yuehui Union Foundation ofGuangdong Province in 2022. The laboratory is well funded, and thecurrent team is comprised of senior scientists, post-doctoral fellows,technicians and Masters students. The research group works well together.
International Collaborations： Professors Mark Kilby and Martin Hewison （University of Birmingham， UK）– Vitamin D and early pregnancy Dr Annette Meeson （Newcastle University， UK） – Cancer stem cells and angiogenesis Dr Jane Girling (University of Otago, NZ) - Heavy menstrual bleeding and obesity
Representative Research Grants Awarded： (1)广东省基础与应用基础研究区域联合基金-重点项目，《内分泌干扰物通过调控子宫内膜表观遗传变化诱导复发性流产的机制研究》，2022-2025，100万元，负责人为GendieE Lash，在研； (2) 国家自然科学基金面上项目，《Ang-2 调控妊娠早期螺旋动脉血管平滑肌细胞去分化和侵袭的机制研究》，2018-2022，59万，负责人为Gendie E Lash，结题； (3) 国家自然科学基金面上项目，《TGF-β1 对子宫内膜增生及成熟的调控作用研究》，2017-2020，57万元，负责人为Gendie E Lash，结题； (4) 广州市科技厅产学研协同创新重大专项，《维生素 D缺乏导致新生儿体重过轻的病因学研究》，2017-2022，200万元，负责人为Gendie E Lash，结题； (5) 国家自然科学基金委员会青年科学基金项目，《TGF-β1通过下调ALKBH5影响 m6A RNA甲基化抑制子宫螺旋动脉平滑肌细胞表型转换的机制研究》，2024-2026，30万元，负责人为甘晓文，在研； (6) 国家自然科学基金委员会青年科学基金项目，项目编号：81702567，HE4通过Smad信号通路对子宫内膜癌细胞周期的调控机制研究，2018-2020，20万，负责人为卢勤声，结题； (7) 国家自然科学基金委员会青年科学基金项目，《14-3-3ζ/ezrin复合物调控Rac1活化促进乳腺癌细胞迁移的分子机制》，2018-2020，18万，负责人为陈妙娟，结题； (8) 国家自然科学基金委员会青年科学基金项目，《Noda1疫茴刈恶性黑色素瘤的防治作用及机制研究》，2017-2019，20万元，负责人为宁粉，结题。
Research Awards and Fellowships： (1) Gendie E Lash入选2016年广州市医学重点人才 (2) Gendie E Lash 入选2021年珠三角自主创新示范区9市和揭阳中德金属生态城外籍高层次人才 (3) Gendie E Lash获得2021年和2023年高端外国专家引进计划个人项目奖 (4)Gendie E Lash获得2023全球前2%科学家称号
Selected Recent Representative Publications： Maternal adaptation to early pregnancy (1) Long Y, Zeng S, Gao F, Liu F, Zhang Y, Zhou C, Zhu C, Zhao X, Han M,Gan Q, Ye W, Zeng F, Song C, Jiang M, Lash GE, Yang H. SERPINA5 maypromote the development of preeclampsia by disruption of the uPA/uPARpathway. Transl Res. 2023 Jan;251:14-26. doi:10.1016/j.trsl.2022.06.011. Epub 2022 Jun 15. PMID: 35717024. (IF=10.171) (2) Liu H, Chen M, Ning F, Ye Y, Lu Q, Lu S, Duan Y, Gan X, Zhao M, GuoK, Lash GE. Extravillous trophoblast cell-derived exosomes inducevascular smooth muscle cell apoptosis via a mechanism associated withmiR-143-3p. Mol Hum Reprod. 2023 Jul 31;29(8):gaad026. doi:10.1093/molehr/gaad026. PMID: 37369038.（IF=4.0） (3) Hou H, Ning F, Zhang JY, Lu Q, Zhang M, Wu P, Chen M, Lash GE.Angiopoietin 2 stimulates trophoblast invasion via a mechanismassociated with JNK signaling. Mol Hum Reprod. 2021 Feb27;27(3):gaab014. doi: 10.1093/molehr/gaab014. PMID: 33629098. (IF=6.081) (4) Zhang JY, Wu P, Chen D, Ning F, Lu Q, Qiu X, Hewison M, Tamblyn JA,Kilby MD, Lash GE. Vitamin D Promotes Trophoblast Cell InducedSeparation of Vascular Smooth Muscle Cells in Vascular Remodeling viaInduction of G-CSF. Front Cell Dev Biol. 2020 Dec 22;8:601043. doi:10.3389/fcell.2020.601043. PMID: 33415106; PMCID: PMC7783206. (IF=6.081) (5) Lash GE, Pitman H, Morgan HL, Innes BA, Agwu CN, Bulmer JN. Decidualmacrophages: key regulators of vascular remodeling in human pregnancy. JLeukoc Biol. 2016 Aug;100(2):315-25. doi: 10.1189/jlb.1A0815-351R. Epub2016 Jan 27. PMID: 26819320.（IF=6.011）
Gynecological cancers (6) Chen M, Pan Y, Liu H, Ning F, Lu Q, Duan Y, Gan X, Lu S, Hou H,Zhang M, Tian Y, Lash GE. Ezrin accelerates breast cancer livermetastasis through promoting furin-like convertase-mediated cleavage ofNotch1. Cell Oncol (Dordr). 2022 Dec 29. doi:10.1007/s13402-022-00761-x. Epub ahead of print. PMID: 36580262. (IF=7.051) (7) Duan Y, Yu J, Chen M, Lu Q, Ning F, Gan X, Liu H, Ye Y, Lu S, LashGE. Knockdown of heat shock protein family D member 1 (HSPD1) promotesproliferation and migration of ovarian cancer cells via disrupting thestability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). J Ovarian Res.2023 Apr 22;16(1):81. doi: 10.1186/s13048-023-01156-8. Erratum in: JOvarian Res. 2023 May 11;16(1):91. PMID: 37087461; PMCID: PMC10122320.(IF=4.0) (8) Zhang M, Lu Q, Hou H, Sun D, Chen M, Ning F, Wu P, Wei D, Duan Y,Pan Y, Lash GE. Garcinol inhibits the proliferation of endometrialcancer cells by inducing cell cycle arrest. Oncol Rep. 2021Feb;45(2):630-640. doi: 10.3892/or.2020.7900. Epub 2020 Dec 15. PMID:33416149; PMCID: PMC7757109. (IF=5.435) (9) Shi K, Wang Q, Su Y, Xuan X, Liu Y, Chen W, Qian Y, Lash GE.Identification and functional analyses of differentially expressedmetabolites in early stage endometrial carcinoma. Cancer Sci. 2018Apr;109(4):1032-1043. doi: 10.1111/cas.13532. Epub 2018 Mar 25. PMID:29436067; PMCID: PMC5891202. (IF=6.518)
Endometrial disorders (10) Lu Q, Sun D, Shivhare SB, Hou H, Bulmer JN, Innes BA, Hapangama DK,Lash GE. Transforming Growth Factor (TGF) β and Endometrial VascularMaturation. Front Cell Dev Biol. 2021 Apr 9;9:640065. doi:10.3389/fcell.2021.640065. PMID: 33898426; PMCID: PMC8063037. (IF=4.518) (11) Lu Q, Huang Y, Wu J, Guan Y, Du M, Wang F, Liu Z, Zhu Y, Gong G,Hou H, Zhang M, Zhang JY, Ning F, Chen L, Wang L, Lash GE. T-cadherininhibits invasion and migration of endometrial stromal cells inendometriosis. Hum Reprod. 2020 Jan 1;35(1):145-156. doi:10.1093/humrep/dez252. PMID: 31886853. (IF=6.353) (12) Biswas Shivhare S, Bulmer JN, Innes BA, Hapangama DK, Lash GE.Endometrial vascular development in heavy menstrual bleeding: alteredspatio-temporal expression of endothelial cell markers and extracellularmatrix components. Hum Reprod. 2018 Mar 1;33(3):399-410. doi:10.1093/humrep/dex378. PMID: 29309596. (IF=6.353)