瑞典卡罗琳斯卡学院再生生物学博士后岗位

Institution

Karolinska Institute
(http://www.dbrm.se) 

Location

Stockholm, Sweden

Position

Postdoctoral scientist - regeneration biology

Date Posted

Sep 6th 2007

Description

A postdoctoral position in regeneration biology is available in the lab of András Simon at the Karolinska Institute, Stockholm, Sweden.

Natural examples of regeneration, such as salamanders, may unravel novel strategies for cell replacement of damaged or lost tissues. We study regeneration mechanisms in an aquatic salamander, the newt, which has the widest repertoire of regenerative abilities among adult vertebrates.

Our group has two main interests.

The first dimension of our research is to understand how skeletal muscle contributes to new tissues during limb regeneration. We have identified a multipotent stem cell population in salamander skeletal muscle and we try to understand how these cells take part in limb regeneration. Salamander skeletal muscle may also undergo a unique dedifferentiation process during limb regeneration, and we aim to reveal the mechanisms underlying skeletal muscle dedifferentiation.

The second dimension of our research is to reveal how brain regeneration can take place. Here we focus at neurogenesis/regeneration of adult dopaminergic neurons in a salamander model of Parkinson s disease. The role of GFAP expressing neural stem cells is currently in the focus of our research and we aim to understand how these are activated in the early phases of dopaminergic regeneration.

Candidates must have a PhD degree and should have advanced knowledge in cell and molecular biology. Research experience with animals is of advantage.

Selected References:

Parish, C.L., Beljajeva, A., Arenas, E., A. Simon. 2007. Midbrain Dopaminergic Neurogenesis and Behavioral Recovery in a Salamander Lesion-Induced Regeneration Model. Development, 134(15):2881-7

Loof, S, Straube, W, Drechsel, D, Tanaka, EM, Simon, A. Plasticity of mammalian myotubes upon stimulation with a thrombin-activated serum factor. Cell Cycle, 2007, 6(9):1096-101

Morrison JI, Loof S, He P, Alestrom P, Collas P, Simon A. Targeted gene delivery to differentiated skeletal muscle: A tool to study dedifferentiation. Dev Dyn. 2007 Feb;236(2):481-8.

Morrison, JI, Lööf, S, He, P, Simon A. Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J Cell Biol. 2006 Jan 30;172(3):433-40.

Contact

Karolinska Institute
(http://www.dbrm.se)