田纳西州圣犹大儿童医院遗传稳定性研究博士后岗位
日期：2008-03-14
来源：丁香人才网
InstitutionSt. Jude Children's Research Hospital (http://www.stjude.org)PositionPostdoc Kitagawa Lab St Jude MemphisLocationMemphis TN USADate PostedMarch 12th 2008Date ExpiresJune 11th 2008Tagsst jud ...
Institution
St. Jude Children's Research Hospital (http://www.stjude.org)
Position
Postdoc, Kitagawa Lab, St Jude, Memphis
Location
Memphis, TN, USA
Date Posted
March 12th 2008
Date Expires
June 11th 2008
Tags
st jude, c elegans, postdoc, memphis, tn, and usa
Description
A Postdoctoral position is available immediately to study the mechanismsof regulatory system by which genetic stability is maintained duringcell cycle progression. Our research effort is focused on elucidation ofthe molecular mechanisms of cell cycle checkpoint including the mitoticcheckpoint and DNA damage checkpoint utilizing genetic and physiologicalapproaches in both nematode, C. elegans and mouse (M. musculs).
Applicants must have a Ph.D. in the area of molecular biology,biochemistry. Expertise in cell biology, biochemistry, or genetics, ishighly desirable.
St. Jude Children’s Research Hospital has (http://www.stjude.org/) ahighly interactive research environment and state-of-the-art facilitiesincluding core laboratories for proteomics, microarray analysis of geneexpression, transgenic/knock-out mouse technology, etc. (http://recruit.sciencemag.org/feature/profile/stjude.shl)
Contact
Send curriculum vitae and three references to:
Dr. Risa Kitagawa,
Dept. Molecular Pharmacology,
St. Jude Children’s Research Hospital,
332 N. Lauderdale St., Memphis, TN 38105-2794 USA.
E-mail: Risa.Kitagawa@stjude.org
Webpage: http://www.stjude.org/kitagawa_r
SJCRH is an Equal Opportunity/Affirmative Action Employer.
References
1. Watanabe S., Yamamoto T.G., Kitagawa R.,
Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferationin response to nutrition signals in C. elegans. EMBOJ. 2008; in press.
2. Tarailo M., Kitagawa R., Rose A.M. Suppressors of spindle checkpointdefect (such) mutants identify new mdf-1/MAD1 interactors inCaenorhabditis elegans. Genetics. 2007; April:175(4): 1665-79
3. Bekker-Jensen S., Lukas C., Kitagawa R., Melander F., Kastan M.B.,Bartek J., and Lukas J. Spatial organization of the mammalian genomesurveillance machinery in response to DNA strand breaks J.Cell.Biol.2006; Apr 24;173(2):195-206.
4. Kitagawa R., Kastan M.B. The ATM-Dependent DNA Damage SignalingPathway. Cold Spring Harb Symp Quant Biol. 2005;70:99-109. Review.
5. Morales M., Theunissen J.W., Kim C.F., Kitagawa R., Kastan M.B.,Petrini J.H. The Rad50S allele promotes ATM-dependent DNA damageresponses and suppresses ATM deficiency: Implications for the Mre11complex as a DNA damage sensor. Genes Dev. 2005 Dec 15;19(24):3043-54
6. Kitagawa R., Bakkenist C.J., McKinnon P.J., Kastan M.B.Phosphorylation of SMC1 is the critical downstream event in theATM-NBS1-BRCA1 pathway. Genes Dev. 2004 June 15;18(12):1423-38.
7. Kitagawa R.*, Law E., Tang L., Rose A.M. The Cdc20 homolog, FZY-1 andits interacting protein, IFY-1 are required for proper chromosomesegregation in Caenorhabditis elegans. Curr. Biol. 2002 Dec 23;12 (24):2118-23.
8. Furuta T., Tuck S., Kirchner J., Koch B., Auty R., Kitagawa R., RoseA.M., Greenstein D. EMB-30: an APC4 homologue required formetaphase-to-anaphase transitions during meiosis and mitosis inCaenorhabditis elegans. Mol Biol Cell 2000 Apr;11 (4):1401-19.
9. Kitagawa R., Rose A.M. Components of the spindle-assembly checkpointare essential in Caenorhabditis elegans. Nat Cell Biol. 1999 Dec;1(8):514-21.
St. Jude Children's Research Hospital (http://www.stjude.org)
Position
Postdoc, Kitagawa Lab, St Jude, Memphis
Location
Memphis, TN, USA
Date Posted
March 12th 2008
Date Expires
June 11th 2008
Tags
st jude, c elegans, postdoc, memphis, tn, and usa
Description
A Postdoctoral position is available immediately to study the mechanismsof regulatory system by which genetic stability is maintained duringcell cycle progression. Our research effort is focused on elucidation ofthe molecular mechanisms of cell cycle checkpoint including the mitoticcheckpoint and DNA damage checkpoint utilizing genetic and physiologicalapproaches in both nematode, C. elegans and mouse (M. musculs).
Applicants must have a Ph.D. in the area of molecular biology,biochemistry. Expertise in cell biology, biochemistry, or genetics, ishighly desirable.
St. Jude Children’s Research Hospital has (http://www.stjude.org/) ahighly interactive research environment and state-of-the-art facilitiesincluding core laboratories for proteomics, microarray analysis of geneexpression, transgenic/knock-out mouse technology, etc. (http://recruit.sciencemag.org/feature/profile/stjude.shl)
Contact
Send curriculum vitae and three references to:
Dr. Risa Kitagawa,
Dept. Molecular Pharmacology,
St. Jude Children’s Research Hospital,
332 N. Lauderdale St., Memphis, TN 38105-2794 USA.
E-mail: Risa.Kitagawa@stjude.org
Webpage: http://www.stjude.org/kitagawa_r
SJCRH is an Equal Opportunity/Affirmative Action Employer.
References
1. Watanabe S., Yamamoto T.G., Kitagawa R.,
Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferationin response to nutrition signals in C. elegans. EMBOJ. 2008; in press.
2. Tarailo M., Kitagawa R., Rose A.M. Suppressors of spindle checkpointdefect (such) mutants identify new mdf-1/MAD1 interactors inCaenorhabditis elegans. Genetics. 2007; April:175(4): 1665-79
3. Bekker-Jensen S., Lukas C., Kitagawa R., Melander F., Kastan M.B.,Bartek J., and Lukas J. Spatial organization of the mammalian genomesurveillance machinery in response to DNA strand breaks J.Cell.Biol.2006; Apr 24;173(2):195-206.
4. Kitagawa R., Kastan M.B. The ATM-Dependent DNA Damage SignalingPathway. Cold Spring Harb Symp Quant Biol. 2005;70:99-109. Review.
5. Morales M., Theunissen J.W., Kim C.F., Kitagawa R., Kastan M.B.,Petrini J.H. The Rad50S allele promotes ATM-dependent DNA damageresponses and suppresses ATM deficiency: Implications for the Mre11complex as a DNA damage sensor. Genes Dev. 2005 Dec 15;19(24):3043-54
6. Kitagawa R., Bakkenist C.J., McKinnon P.J., Kastan M.B.Phosphorylation of SMC1 is the critical downstream event in theATM-NBS1-BRCA1 pathway. Genes Dev. 2004 June 15;18(12):1423-38.
7. Kitagawa R.*, Law E., Tang L., Rose A.M. The Cdc20 homolog, FZY-1 andits interacting protein, IFY-1 are required for proper chromosomesegregation in Caenorhabditis elegans. Curr. Biol. 2002 Dec 23;12 (24):2118-23.
8. Furuta T., Tuck S., Kirchner J., Koch B., Auty R., Kitagawa R., RoseA.M., Greenstein D. EMB-30: an APC4 homologue required formetaphase-to-anaphase transitions during meiosis and mitosis inCaenorhabditis elegans. Mol Biol Cell 2000 Apr;11 (4):1401-19.
9. Kitagawa R., Rose A.M. Components of the spindle-assembly checkpointare essential in Caenorhabditis elegans. Nat Cell Biol. 1999 Dec;1(8):514-21.
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