汉堡-Eppendorf医学中心肿瘤靶向博士后

Post-Doc : Hamburg, Germany

Employers:

Universitatsklinikum Hamburg-Eppendorf

Location(s):

Hamburg, Germany

Posted:

April 20, 2010

Expires:

May 23, 2010 

Website:

http://www.zmnh.uni-hamburg.de/

Job Tag(s):

hamburg,germany,postdoc,oncology,tumorbiology

Description:

The newly established research group “Targeted Oncology” in the Center for Oncology and Institute for Tumorbiology (group leader: Sonja Loges, M.D., Ph.D.) of the University Hospital-Eppendorf in Hamburg, Germany is seeking a motivated

Post-Doc

Funding is limited to two years, but prolongation for another two years is expected. The project aims at mechanistic analysis of bone marrow micrometastasis in preclinical mouse models of cancer. You can expect an interesting and challenging athmosphere, excellent working conditions and a beautiful harbour city offering a high level of quality of life. The “Targeted Oncology” group is a young group within an internationally staffed institution with many international collaborators.

Your Project: Disseminated Tumor Cells (DTCs) in the bone marrow represent an adverse prognostic factor in different tumor entities. However, besides association with clinical data, many outstanding mechanistic questions remain. For instance, mechanisms of homing, interaction with bone marrow stroma cells and subsequent mobilisation of DTCs are unresolved. This project aims first at establishing in vivo models for DTCs. By using these models, homing, mobilisation and tumor-forming potential of DTcs will de analyzed. Subsequently, influence of different therapeutic modalities on DTCs will be investigated. You are expected to use a wide variety of in vivo and in vitro techniques to conduct these experiments. You will be culturing different tumor cell lines, implant them into mice and treat the animals with different therapies. Additionally, you will be using molecular biology, protein biochemistry and imaging for mechanistic analysis of DTCs. You will be performing RNA and protein isolation, ELISA, Western Blotting and QRT-PCR. You will transfect eukaryotic cells, use immunofluorescent and other techniques to stain mouse tissues and use confocal microscopy.

Your Skills: You sucessfully completed your Ph.D. in biology, biochemistry, molecular biology or similar studies. You have experience in the described in vivo and in vitro techniques and are used to work independently. Knowledge in conducting mouse tumor models, molecular biology, protein biochemistry, confocal microscopy and histology are an advantage. Your written and spoken English is fluent. Motivation, flexibility and team spirit are your characteristics.

Contact:

Your contact for questions: Sonja Loges; M.D., Ph.D., email: s.loges@uke.uni-hamburg.de, pager +49-15221-2817536

We chose our personnel according to qualification. Disabled persons are preferred, if they hold similar qualifications.

We are looking forward to receive your application until 2010, May 3rd to the Universitätsklinikum Hamburg-Eppendorf, GB Personal, Recht & Organisation, Frau Schild, Kzf.: 2010-04/110, Martinistr. 52, 20246 Hamburg, Germany or via email to: bewerbung@uke-hh.de (max. 2 MB in one pdf-file).