哈佛医学院肿瘤研究所细胞代谢博士后岗位

Institution:

Dana Farber Cancer Institute
Harvard Medical School

Position:

Post Doctoral Position in Cell Death and Metabolism

Job Description：

A post doctoral position is available in the laboratory of Dr. Nika Danial, Ph.D of the Department of Cancer Biology at Dana-Farber Cancer Institute to dissect key molecular mechanisms underlying the cross talk between cellular survival and metabolism. This laboratory has distinct scientific expertise in the role of BCL-2 family proteins in normal mitochondrial physiology and in apoptosis. The broad aims of this project are to identify and dissect energy and nutrient sensing pathways, including metabolic checkpoints that converge on BCL-2 family proteins to control cellular survival as well as bioenergetics. We employ a multi-disciplinary approach that draws on mouse genetics, mitochondrial metabolism, shRNA library screens, chemical biology and proteomics. The research goals designed for this position have implications for multiple diseases, including, cancer, neurodegeneration and diabetes.

This position is for highly motivated candidates who thrive on intellectual challenges and have a strong desire to expand their skillscope. The minimum requirement for this position is a PhD and/or MD degree. A strong background in biochemistry, cell biology or molecular biology and familiarity with techniques such as RNA interference, imaging and FACS analysis are preferred.

Primary research activities envisioned for this position include examination of changes in cellular metabolic profile in loss- and gain-of-function models of BCL-2 family members, including changes in cellular ATP regenerating systems and oxidative capacity. This may also include identification of novel interaction partners and non-apoptotic functions for BCL-2 proteins.

The Dana-Farber Cancer Institute is a world-leader in clinical cancer care and basic research, and has committed significant, newly-renovated laboratory space for fostering junior faculty research programs. Interested candidates should submit electronic copy of their curriculum vitae, along with complete contact information for at least three references and a cover letter which includes past research experience, career goals and a statement of interested in this particular position to:

Contact:

Nika N. Danial
Cancer Biology
Dana-Farber Cancer Institute
44 Binnay Street
Smith 758
Boston, MA 02115
United States
Phone: 617-632-6436
Fax: 617-632-6401
Email: nika_danial@dfci.harvard.edu