希腊Pasteur学院蛋白质晶体学博士后岗位

Institution

Hellenic Pasteur Institute

Position

Postdoctoral Fellowship in Protein Crystallography

Location

Athens, Greece

Date Posted

Aug 29 2007

Description

A postdoctoral position for a protein crystallographer is immediately available at the Laboratory of Molecular Neurobiology and Immunology, Department of Biochemistry of the Hellenic Pasteur Institute, Athens, Greece (www.pasteur.gr). The major part of the activities of the lab involves the expression of extracellular domains (210-220 amino acids long) of several subunits of human nicotinic acetylcholine receptors in eukaryotic expression systems, construction of mutant forms, purification and, recently, crystallization and co-crystallization efforts. The lab has some past expertise in protein crystallography (2 Fab fragments) but the new post-doc will be now the main crystallographer of the group.
The new post-doc should have extensive expertise in protein crystallization and considerable expertise in crystallographic analysis. Expertise in molecular biology approaches is useful but not necessary.
S/he will collaborate closely with members of the lab (mostly with expertise in molecular biology & biochemistry) who currently produce sufficient amounts of wt and mutant forms of the AChR domains in various expression systems, and with collaborating crystallographers in neighbouring labs. The main task of the post-doc will be to obtain diffraction quality crystals of these domains and their subsequent structure determination (of fundamental importance for subsequent drug design). May also be involved with new expressions.
The lab is supported by several international grants (3 EC grants, 2 MDA, 1 AFM etc) and has (or has access to) all needed equipment. The post will be supported by an EC grant.

Contact

Please send a preliminary request with a CV and a summary of research experience and interests to Prof. Socrates Tzartos, emails: tzartos@pasteur.gr and tzartos@upatras.gr.