丁香园网友nkhyjin推荐葡萄牙博后信息之二：老年化和疾病易感性

感谢丁香园网友nkhyjin的推荐，葡萄牙博后信息之二：老年化和疾病易感性
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GOVERNO REGIONAL DOS AÇORES
SECRETARIA REGIONAL DA EDUCAÇÃO E CIÊNCIA
FUNDO REGIONAL DA CIÊNCIA E TECNOLOGIA

ANNOUNCEMENT

SELECTION PROCEDURE M112/FRCT/2007 – SCHOLARSHIP NUMBER 12

EXTENT AND DEADLINE

1 – According with the Portuguese Law nº40/2004, dated August 18th, and with the General Regulation for Scientific Research Scholarships and Management Support of the Science and Technology Regional Fund (Regulamento Geral de Bolsas de Investigação Científica e de Apoio à Gestão do Fundo Regional da Ciência e Tecnologia), available in the Regional Government of the Azores Internet site (http://sctr.azores.gov.pt), we hereby announce that until September 30th, 2007, applications can be submitted for the attribution of a post-doctorate scholarship..

2 – The post-doctorate scholarship derives from the Measure 1.1.2/FRCT – Reinforcement of research teams for accredited R&D Units (Medida 1.1.2/FRCT – Reforço das equipas de investigação das Unidades de I&D acreditadas), funded by the Science and Technology Regional Fund in the frame of the Science and Technology Integrated Plan (Plano Integrado para a Ciência e Tecnologia).

PROJECT

3 – The scholarship aims the development of the project “Aging and susceptibility to infections”.

4 – The main goal of this project is to find an answer to the following question – why oldest organisms are more susceptible to infections than youngest? This is a core question nowadays, when life expectance is increasing continuously world wide and easier communications expose people to new infectious agents. In fact, old people generally are more susceptible to infections, react badly to actual pharmaceuticals, and have a higher rate of adverse reactions to usual therapies than young people. It is clear that the immune system becomes senescent with age however those modifications are not sufficient to explain the highest susceptibility to infections of older persons. To answer this challenge is mandatory to understand basic mechanisms involved in aging process. Many of these studies can not be accomplished with success in humans so animal models must be used.
Several authors studied worms for this purpose. In CIRN laboratories we are studding a worm, which has the specificity of being associated with an entomopathogenic bacteria. We are using the complex nematode-bacteria to control insect pests and to study molecular mechanism of pathogenicity. We perform proteogenomic studies on translational factors has expressed gene analysis using Northernblot, differential dysplay, RT-PCR, cDNA cloning and sequencing, and we are doing siRNA and microinjection. Concerning proteomics we perform 2DE and FPLC enrichment and we have a protocol with ITQB for MALDI-TOF e LC-MS/MS facilities and with CNC for recombinant expression of identified cDNAs. Moreover we perform protein-protein interactions. Bioinformatics is also being used for proteogenomics analysis.
As result of the developed research several tools can be used in this project. From the nematode we have selected strains with high and short longevity, we have genetic high relevant information on this organisms including cDNA libraries of both strains, and from old and aged organisms, protein profiles of these same organisms under different physiological situations including juveniles with higher and lower resistance to bacteria, sequenced mtDNA, etc. We have also a DNA library of the associated bacteria. This complex nematode / bacteria is presently used as a model to study human infections in medicine research laboratories with success.

5 – The work will be developed at the CIRN (http://www.cirn.uac.pt/) , in the University of Azores, based in São Miguel Island, Azores, Portugal under the coordination of Professor Doutor Nelson Simões (simoes@notes.uac.pt).

CONDITIONS

6 – The contract to be established is for a one year period, renewable up to a maximum of three years, and is foreseen to begin in November 1st 2007.
 
7 – The scholarship-holder will benefit of: (a) a monthly subsidy of 1.750 Euros; (b) a subsidy which aims to compensate the Social Security duties and (c) a personal accident insurance. The scholarship-holder will also be able to apply for a settling support subsidy, including the payment of travel expenses related with the first trip up to a maximum of 1.000 Euros and a housing aid of 500 Euros.

CANDIDATE PROFILE

8 – The candidate must have a PhD in Cellular or Developmental Biology or in Molecular Biology or Genetics. He should have experience in laboratory work and good skills in spoken and written English.

APPLICATIONS

9 – The applications should be formalized by electronic submission of the form made available in the Internet site http://sctr.azores.gov.pt.

10 – To access this form, those interested will have to make a pre-registration in the Scientific and Technological Regional System (Sistema Científico e Tecnológico Regional) through the Internet site mentioned above.

11 – In the application form, those interested will have to attach the confirming certificate of their Doctoral degree or, if such is not available, indicate the date of when the degree was attained, as well as the thesis title and the name of the institution which granted the degree.

12 – Non-withstanding the previous number, the original or an authenticated copy of the Doctoral degree certificate will have to be delivered up to the date of the contract signature.

13 – The application processes that are not completed until the submission deadline will be automatically excluded.

EVALUATION CRITERIONS

14 – The evaluation criteria will take into account the candidate’s curriculum vitae and the proposed work plan.

ADDITIONAL INFORMATION

15 – Any additional information can be solicited to the Science and Technology Regional Fund, Rua Conselheiro Dr. Luís Bettencourt nº 16, 9500-058 Ponta Delgada, through the telephone +351 296206500, Fax +351 296206591 or e.mail Maria.BC.Rego@azores.gov.pt .

Ponta Delgada, 29 de Agosto de 2007.

 Pelo Conselho Administrativo do FRCT.

João Luís Gaspar
Presidente