德国海德堡大学招聘博士后

日期：2012-06-02 来源：海外博士后

Replication of major human pathogens such as Human Immunodeficiency Virus Type 1 (HIV -1) is potently suppressed by intrinsic and adaptive immunity strategies of the host. Consequently HIV -1 has evolved gene products that allow circumvention of these immune responses. One focus of the laboratory is on deciphering the mechanism by which the HIV -1 protein Vpu antagonizes the restriction imposed by the host factor CD317/tetherin to the release of mature virus particles (Goffinet et al. 2009 Cell Host & Microbe; Goffinet et al. 2010 J. Virol.; Schmidt et al. 2011 MBio; Fritz et al. 2012 Virology). Another goal is to understand how the HIV -1 protein Nef undermines mounting of adaptive immunity by interference with immune cell interactions of infected T lymphocytes (Pan et al. 2012 Blood; Stolp et al. 2009 Cell Host & Microbe). Open projects are available in both lines of research.

The Department of Infectious Diseases, Virology at the University Hospital Heidelberg, Germany offers a

postdoc position (TVL E13) for two years (extension possible)

starting summer 2012

in the laboratory of Prof. Dr. Oliver Fackler.

Replication of major human pathogens such as Human Immunodeficiency Virus Type 1 (HIV -1) is potently suppressed by intrinsic and adaptive immunity strategies of the host. Consequently, HIV -1 has evolved gene products that allow circumvention of these immune responses. One focus of the laboratory is on deciphering the mechanism by which the HIV -1 protein Vpu antagonizes the restriction imposed by the host factor CD317/tetherin to the release of mature virus particles (Goffinet et al., 2009, Cell Host & Microbe; Goffinet et al., 2010, J. Virol.; Schmidt et al., 2011, MBio; Fritz et al., 2012, Virology). Another goal is to understand how the HIV -1 protein Nef undermines mounting of adaptive immunity by interference with immune cell interactions of infected T lymphocytes (Pan et al., 2012, Blood; Stolp et al., 2009, Cell Host & Microbe). Open projects are available in both lines of research.

The successful candidate will have a strong background and practical experience in biochemical analyses of protein interactions and light microscopy. We expect a strong interest in cell biology, virology and immunology, creative and independent research, and a very high level of motivation. We offer interesting research topics with biomedical relevance in a stimulating and interactive scientific environment at an internationally competitive level. Please send your applications with full CV including list of publications and letter of motivation until June 14 to:

Prof. Dr. Oliver T. Fackler

Department of Infectious Diseases, Virology

University Hospital Heidelberg

Im Neuenheimer Feld 324

69120 Heidelberg

phone: +49- (0)6221-56-1322

fax: +49- (0)6221-56-5003

Email: oliver_fackler@med.uni-heidelberg.de

homepage http://www.klinikum.uni-heidelberg.de/Fackler.6555.0.html

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