爱荷华州立大学微生物研究博士后岗位

Institution

University of Iowa

Position

postdoctoral postion

Salary

The position is supported by an NIH grant and salary is according to NIH guidelines (starting salary ~ $37,000 per year, plus benefits).

Location

Iowa City, Iowa, USA

Date Posted

Sep 28 2007

Description

Postdoctoral Position available to investigate host-pathogen interaction using Anaplasma phagocytophilum infection of neutrophils as a model. Studies include (1) signal transduction in neutrophils, (2) the role of AnkA in inhibition of the neutrophil respiratory burst (3) the mechanism resulting in the delay of apoptosis in neutrophils infected with Anaplasma phagocytophilum.

We are studying the basic molecular mechanisms involved in the survival of Anaplasma phagocytophilum in neutrophils. This organism is unusual because it is the only human pathogen that survives in neutrophils. AnkA is a bacterial virulence factor that is translocated by a type four secretion system (TFSS) into the neutrophil. After translocation AnkA is phosphorylated on tyrosines by Src kinases, allowing it to interact with SH2-domain-containing host proteins. We intend to determine what signaling pathways are affected by AnkA, and its role in the inhibition of the respiratory burst and the delay of apoptosis.

The successful candidate should have a Ph.D. in Microbiology/Immunology or M.D. degree, experience in the study of cell signaling/phagocyte biology, a strong publication track record, and be highly motivated. The lab is located in a state of the art research facility with new equipment and an excellent educational environment.

Contact

Please e-mail to jacob-ijdo@uiowa.edu or send CV, a brief description of research experiences, and contact information for 3 references to:

Jacob IJdo, M.D., Ph.D.
Department of Internal Medicine
University of Iowa College of Medicine
200 Hawkins Drive
C31M-GH
Iowa City, IA 52242
USA