德国法兰克福某研究中心招收博士后职位

The Research Centre in Frankfurt, Germany has vacancies for:

3 Postdocs (f/m)

Your responsibilities
Department: Computational Toxicology
Ph.D. level scientist for the development of new prediction models of drug toxicity in different species including man. The models will cover single mechanism as well as more complex toxicity endpoints like organ toxicity (including reactive metabolites), developmental toxicity, off-target related side effects etc. Key approaches are the use of new data from public sources (e.g. FDA -CDER , ToxCast, Tox21), consortia (e.g. IMI eTOX) and internal proprietary toxicity reports. The use of new integrated prediction approaches include QSAR , statistical and PBPK models and virtual simulations (analog virtual liver/embryo projects). The individual will work in close partnership with other scientists in Structure, Design & Informatics, PK/PD and with the scientific and regulatory community outside Sanofi.

Department: Modelling & Simulation / Pharmacometrics
Ph.D. level Scientist who is driven to use quantitative approaches to understand the Clinical Pharmacokinetics and Pharmacodynamics of novel insulin analogues at the molecular level. This individual will be responsible for the development and implementation of molecular mechanistic models of the insulin signalling processes in different tissues to support the discovery of novel insulin analogues. Key technical responsibilities are to organize, execute, and report modeling and simulation, as well as to present work at cross-functional teams, department meetings, and conferences. The individual will work in close partnership with other scientists in Computational Biology, Clinical Pharmacology, PK/PD, Biostatistics, and project teams.

Department: Nucleic Acid Therapeutics Platform
• Ph.D. level scientist for the Development and preparation of nanoparticles for delivery into cells, tissues and organs
• Formulation of siRNA, characterization, test of stability and release
• Proof-of-concept studies in animal models
• The candidate will support a multi-disciplinary team composed of nucleic acid chemists, molecular biologists, and pharmacologists

Your qualifications
Department: Computational Toxicolgy
Candidates for this post should have a Ph.D. in Computer Modeling, Chemoinformatics or a related field. Demonstrated expertise in the area of model development, computer modelling and simulations including respective software is key. Prior experience in toxicology and the modelling of toxicity endpoints is a plus. The candidate should have excellent communication (business fluent English, German of advantage) and interpersonal skills and the ability to work independently and effectively in an interdisciplinary environment.

Department: Modelling & Simulation / Pharmacometrics
Candidates interested in this area should have a Ph.D. in Biomedical Engineering, Pharmacometrics or a related field. Demonstrated expertise in the area of dynamic modelling of biological systems and strong hands-on skills are required. Experience with Matlab, Simbiology, Copasi or other modelling and simulation software is preferred. Prior experience with modelling of cellular or physiological systems in diabetes area is a plus. The candidate must have excellent communication (English and/or German) and interpersonal skills and the ability to work independently and effectively on interdepartmental project teams.

Department: Nucleic Acid Therapeutics Platform
• Candidates for this post should have a recent PhD in materials science, chemistry, pharmaceutical technology or biomaterial nanotechnologies
• Solid experience in characterization of nanomaterials, polymers and large biomolecules

Our offer
Duration: 24 Months
If you are interested, please send us your online application under www.sanofi.de/karriere

Sanofi-Aventis Deutschland GmbH
HR Recruitment Services
Industriepark Höchst • Gebäude K 703
D-65926 Frankfurt am Main