芝加哥大学血液肿瘤和干细胞转移研究博士后岗位
日期：2007-11-14
来源：丁香人才网
InstitutionUniversity of ChicagoPositionPostDoctoral PositionsLocationChicago IllinoisDate PostedNov 12th 2007DescriptionThe Department of Pediatrics Section of Hematology Oncology and Stem Cell Trans ...
Institution
University of Chicago
Position
PostDoctoral Positions
Location
Chicago, Illinois
Date Posted
Nov 12th 2007
Description
The Department of Pediatrics Section of Hematology Oncology and StemCell Transplantation at the University of Chicago is recruitingPost-Doctoral Fellows for research in various areas. Candidates willhave an opportunity to work in the laboratories of well establishedinvestigators. All applicants should hold an M.D. or Ph.D degree. Thesuccessful applicant should have a strong potential to develop anoutstanding independent research program, and be committed to excellencein research.
Eric C. Beyer, MD, PhD -(ebeyer@peds.bsd.uchicago.edu) My laboratory iscurrently investigating the process of intercellular communication; ourspecific goal is a molecular understanding of the structure and functionof gap junctions. Gap junctions are the specialized plasma membranestructures that contain low resistance channels linking adjacent cells.In excitable tissues, they permit electrical coupling; in non-excitabletissues, they permit passage of small molecules involved in metabolicsupport, growth control, and embryogenesis. They may also facilitatedrug metabolite delivery between cells.
Susan Cohn, MD- (scohn@peds.bsd.uchicago.edu) The lab’s research isfocused on the biology of the pediatric cancer neuroblastoma (NB) whichis the most common extracranial solid tumor in childhood. NB isremarkable for its broad spectrum of clinical behavior and despite themost intensive treatment regimens, long term survival in children over 1year old at diagnosis and with metastatic disease is less than 20%.Therefore, new therapeutic approaches are needed to achieve betterlong-term outcomes for these children. The goal of the lab is to utilizein vitro and in vivo models to study this disease and potentialtreatment strategies.
John M. Cunningham, MD- (jcunning@peds.bsd.uchicago.edu) Primaryresearch interests are the biology and therapy of hemoglobinopathies,elucidation of transcriptional mechanisms operative during developmentof vertebrate organisms and the development of novel clinical trials fortreatment of genetic diseases.
Kenan Onel, MD, PhD- (konel@peds.bsd.uchicago.edu) My lab studies thegenetic basis of cancer susceptibility. Using both genome-wide andcandidate gene approaches, our goal is to discover the critical sourcesof inherited genetic variation that predispose individuals to cancer. Wehope that these: 1) will be clinically useful as biomarkers of cancerrisk by which cancer prevention strategies can be individualized basedon each person’s unique genetic endowment; and 2) will point towardsnovel targets for new rationally designed molecular chemotherapeuticsthat short circuit abnormal pathways in cancer cells while sparingcancer patients the toxicities of currently used treatments.
Stephen Skapek, MD- (sskapek@peds.bsd.uchicago.edu) Primary goals are toadvance laboratory-based research projects exploring the mechanism ofaction of key mammalian tumor suppressor genes and understanding theirfunction during cellular differentiation and embryonic development.Current focuses include (1) p19Arf and its role in vascular involutionin the developing eye; (2) p53 and its role in brain development andoncogene-induced senescence in brain tumors; and (3) RB and its role inskeletal muscle differentiation and skeletal muscle-derived cancers.Experimental approaches take advantage of existing mouse models and cellculture-based systems and may include the development of new mousemodels to address specific experimental questions. Standard molecularand cellular biology and histology techniques are routinely used.
Samuel Volchenboum, MD, PhD- (svolchen@peds.bsd.uchicago.edu) Theprimary goal of my laboratory is to develop a research program based onthe integrative approach to the study of disease. Starting withneuroblastoma as a model, I am using quantitative proteomic techniquesto study the etiology of this aggressive tumor. Using stable isotopelabeling with amino acids in cell culture (SILAC) followed by massspectrometry, I am comparing the levels of protein expression betweenneuroblastoma cell lines that overexpress the MYCN oncogene and thosehave normal MYCN expression. In addition to identifying differentiallyexpressed proteins, I will leverage orthogonal data sets and design andbuild unique informatic systems to bring together data from seeminglydisparate sources. The application of these techniques will be appliedto other solid tumors.
Contact
Interested applicants send CV and three letters of recommendations tothe appropriate investigators attention at The University of Chicago,Department of Pediatrics, 5841 South Maryland Avenue, MC 4060 Chicago,IL 60637 or via email.
University of Chicago
Position
PostDoctoral Positions
Location
Chicago, Illinois
Date Posted
Nov 12th 2007
Description
The Department of Pediatrics Section of Hematology Oncology and StemCell Transplantation at the University of Chicago is recruitingPost-Doctoral Fellows for research in various areas. Candidates willhave an opportunity to work in the laboratories of well establishedinvestigators. All applicants should hold an M.D. or Ph.D degree. Thesuccessful applicant should have a strong potential to develop anoutstanding independent research program, and be committed to excellencein research.
Eric C. Beyer, MD, PhD -(ebeyer@peds.bsd.uchicago.edu) My laboratory iscurrently investigating the process of intercellular communication; ourspecific goal is a molecular understanding of the structure and functionof gap junctions. Gap junctions are the specialized plasma membranestructures that contain low resistance channels linking adjacent cells.In excitable tissues, they permit electrical coupling; in non-excitabletissues, they permit passage of small molecules involved in metabolicsupport, growth control, and embryogenesis. They may also facilitatedrug metabolite delivery between cells.
Susan Cohn, MD- (scohn@peds.bsd.uchicago.edu) The lab’s research isfocused on the biology of the pediatric cancer neuroblastoma (NB) whichis the most common extracranial solid tumor in childhood. NB isremarkable for its broad spectrum of clinical behavior and despite themost intensive treatment regimens, long term survival in children over 1year old at diagnosis and with metastatic disease is less than 20%.Therefore, new therapeutic approaches are needed to achieve betterlong-term outcomes for these children. The goal of the lab is to utilizein vitro and in vivo models to study this disease and potentialtreatment strategies.
John M. Cunningham, MD- (jcunning@peds.bsd.uchicago.edu) Primaryresearch interests are the biology and therapy of hemoglobinopathies,elucidation of transcriptional mechanisms operative during developmentof vertebrate organisms and the development of novel clinical trials fortreatment of genetic diseases.
Kenan Onel, MD, PhD- (konel@peds.bsd.uchicago.edu) My lab studies thegenetic basis of cancer susceptibility. Using both genome-wide andcandidate gene approaches, our goal is to discover the critical sourcesof inherited genetic variation that predispose individuals to cancer. Wehope that these: 1) will be clinically useful as biomarkers of cancerrisk by which cancer prevention strategies can be individualized basedon each person’s unique genetic endowment; and 2) will point towardsnovel targets for new rationally designed molecular chemotherapeuticsthat short circuit abnormal pathways in cancer cells while sparingcancer patients the toxicities of currently used treatments.
Stephen Skapek, MD- (sskapek@peds.bsd.uchicago.edu) Primary goals are toadvance laboratory-based research projects exploring the mechanism ofaction of key mammalian tumor suppressor genes and understanding theirfunction during cellular differentiation and embryonic development.Current focuses include (1) p19Arf and its role in vascular involutionin the developing eye; (2) p53 and its role in brain development andoncogene-induced senescence in brain tumors; and (3) RB and its role inskeletal muscle differentiation and skeletal muscle-derived cancers.Experimental approaches take advantage of existing mouse models and cellculture-based systems and may include the development of new mousemodels to address specific experimental questions. Standard molecularand cellular biology and histology techniques are routinely used.
Samuel Volchenboum, MD, PhD- (svolchen@peds.bsd.uchicago.edu) Theprimary goal of my laboratory is to develop a research program based onthe integrative approach to the study of disease. Starting withneuroblastoma as a model, I am using quantitative proteomic techniquesto study the etiology of this aggressive tumor. Using stable isotopelabeling with amino acids in cell culture (SILAC) followed by massspectrometry, I am comparing the levels of protein expression betweenneuroblastoma cell lines that overexpress the MYCN oncogene and thosehave normal MYCN expression. In addition to identifying differentiallyexpressed proteins, I will leverage orthogonal data sets and design andbuild unique informatic systems to bring together data from seeminglydisparate sources. The application of these techniques will be appliedto other solid tumors.
Contact
Interested applicants send CV and three letters of recommendations tothe appropriate investigators attention at The University of Chicago,Department of Pediatrics, 5841 South Maryland Avenue, MC 4060 Chicago,IL 60637 or via email.
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