南加州大学洛杉矶儿童医院白血病干细胞研究博士后岗位

Institution

Childrens Hospital Los Angeles, University of Southern California

Position

Postdoctoral scientist: Leukemia stem cells and reprogramming of human B cells

Location

Los Angeles, CA 90027

Date Posted

February 19th 2008

Date Expires

April 19th 2008

Description

The Leukemia Research Program at Childrens Hospital Los Angeles (University of Southern California) represents an interactive group of 21 full-time faculty investigators with shared interest in the molecular biology of acute lymphoblastic leukemia cells. Research areas include i.) genetic instability, ii.) oncogenic signal transduction and iii.) stem cell-derivation of acute lymphoblastic leukemia cells.

A new area of research has recently been initiated to study stem cells in acute lymphoblastic leukemia based on reprogramming of human B cells into induced pluripotent stem cells . We invite applications from motivated postdoctoral scientists with a strong background in molecular cloning and interest in stem cell biology. The position is available immediately. Applications should be sent by E-mail in PDF format and include (1) a personal statement of research and career goals, (2) a CV and publication list and (3) the coordinates of three references.

Inquiries and applications (PDF format only) should be directed by March 15th to Markus Müschen, MD, Director, Leukemia Research Program, Childrens Hospital Los Angeles, at mmuschen@chla.usc.edu.

Recent publications :
a. Feldhahn N, Klein F, Mooster JL, Hadweh P, Sprangers M, Wartenberg M, Bekhite MM, Hofmann WK, Herzog S, Jumaa H, Rowley JD, Müschen M. Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. J Exp Med 201:1837-1852, 2005.
b. Feldhahn N, Rio P, Soh BN, Liedtke S, Sprangers M, Klein F, Wernet P, Jumaa H, Hofmann WK, Hanenberg H, Rowley JD, Müschen M. Deficiency of Bruton’s tyrosine kinase in B cell precursor leukemia cells. Proc Natl Acad Sci USA 102:13266-13271, 2005.
c. Klein F, Feldhahn N, Herzog S, Sprangers M, Mooster JL, Jumaa H, Müschen M. BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cells. Oncogene 25:1118-1124, 2006.
d. Sprangers M, Feldhahn N, Herzog S, Hansmann ML, Reppel M, Hescheler J, Jumaa H, Siebert R, Müschen M. The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. Oncogene 25:5056-5062, 2006.
e. Sprangers M, Feldhahn N, Liedtke S, Jumaa H, Siebert R, Müschen M. SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells. Oncogene 25:5180-5186, 2006.
f. Feldhahn N, Henke N, Melchior K, Duy C, Soh BN, Klein F, von Levetzow G, Giebel B, Li A, Hofmann WK, Jumaa H, Müschen M. Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J Exp Med 204:1157-1166, 2007.
g. Meixlsperger S, Kohler F, Wossning T, Reppel M, Müschen M, Jumaa H. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity 26:323-333, 2007.

Contact

http://www.usc.edu/programs/