加州Isis制药公司RNA技术研究博士后岗位
InstitutionIsis Pharmaceuticals Inc. (http://www.isispharm.com)PositionPost Doctoral FellowLocationCarlsbad CA (San Diego)Date PostedMay 9th 2008Date ExpiresJuly 8th 2008Tagspost doctoral fellow carls ...
Institution
Isis Pharmaceuticals, Inc. (http://www.isispharm.com)
Position
Post Doctoral Fellow
Location
Carlsbad, CA (San Diego)
Date Posted
May 9th 2008
Date Expires
July 8th 2008
Tags
post doctoral fellow, carlsbad, ca, and usa
Description
Isis Pharmaceuticals, Inc. is a leading drug discovery and developmentcompany, focused exclusively on the therapeutic target, RNA. Founded in1989, Isis’ mission is to develop products from its RNA-basedtechnologies, such as antisense. Very little was known about antisensewhen the Company was first established, but its founders envisioned anopportunity to revolutionize the pharmaceutical industry with a moreefficient and targeted means of drug discovery. Since then, Isisscientists have made tremendous progress advancing the science ofantisense, unveiling capabilities that have far exceeded their expectations.
Postdoctoral Fellow (Req. 91)
Individual will study the interactions of Pattern Recognition Receptors(PRR) such as RIG-I and MDA5 with modified oligonucleotides. Thesuccessful candidate will examine the impact of administration ofvarious modified oligonucleotides on host innate immune responses. Theresearch project will focus on the relationship between oligonucleotidecomposition and host interferon responses. This position offers anopportunity for considerable creativity and innovation in a highlyenriched research environment.
The successful postdoctoral fellow will develop and apply new andexisting techniques in protein biochemistry, molecular biology, cellbiology, genomics and virology to study oligonucleotide-PRR interactionsand RNA biochemistry.
The ideal candidate will be highly motivated and have recently obtaineda Ph.D. degree with a strong background in biochemistry, immunology,virology or cell/molecular biology. The candidate will be enthusiasticand able to work independently as well as with a team. Strong skills inprotein and RNA biochemistry as well as molecular biology are essential.Hands on experience with cell culture and molecular biology/biochemicaltechniques such as cloning, northern and western blots,immunoprecipitation, and protein purification is required. Previous workin areas of virology and/or immunology is desirable but not required.
Contact
Interested candidates should forward a CV, including publicationhistory, and a one-page cover letter detailing research interests andprevious experience.
Excellent salary and benefits package offered.
For immediate consideration, please apply online by visiting ourwebsite, www.isispharm.com.
Reference job code: 91
NO PHONE CALLS PLEASE. PRINCIPALS ONLY.
Isis Pharmaceuticals, Inc. is proud to be an EEO/AA M/F D/V Employer.