纽约布鲁克斯Yeshiva大学集落刺激因子研究博士后岗位
日期：2008-06-25
来源：丁香人才网
InstitutionAlbert Einstein College of Medicine Yeshiva University (http://www.aecom.yu.edu/dmb/)PositionPostdoctoral PositionsLocationBronx New YorkDate PostedJune 24th 2008Date ExpiresAugust 23th 200 ...
Institution
Albert Einstein College of Medicine, Yeshiva University (http://www.aecom.yu.edu/dmb/)
Position
Postdoctoral Positions
Location
Bronx, New York
Date Posted
June 24th 2008
Date Expires
August 23th 2008
Tags
yeshiva, albert einstein, bronx, new york, postdoc, and post doc
Description
Laboratory of Dr. E. Richard Stanley
Albert Einstein College Medicine
Research in the Stanley lab (http://www.aecom.yu.edu/dmb/stanley.htm) isfocused in the three areas described below:
1. Colony Stimulating Factor-1 (CSF-1) and Interleukin-34 (IL-34) indevelopment and disease: CSF-1 is the primary growth factor regulatingtissue macrophage and osteoclast production. To study the sites of CSF-1synthesis and the actions of the cell surface and secreted isoforms ofCSF-1, we have developed CSF-1-promoter transgenic mice that exclusivelyexpress each the 3 different isoforms of CSF-1, or reporter genes, in anormal tissue-specific manner. Our targeted inactivation of the CSF-1receptor (CSF-1R) predicted the existence of a second ligand, recentlyidentified as IL-34. We are studying the biology of CSF-1 and IL-34,using transgenic and gene targeting approaches. Studies include theroles of these growth factors in hematopoiesis and gut, brain and skindevelopment and in the enhancement of tumor metastasis.
2. CSF1 receptor signal transduction: We have used proteomic approachesto identify downstream signaling molecules and analyzed the mechanism ofaction of several novel signaling intermediates, including SHP-1, DOK-1,PTP-phi, Cbl and MAYP/PSTPIP2. In current work, we are combiningproteomic and bioinformatic approaches to CSF-1R signaling and studyingCSF-1R structure/function using a novel CSF-1R /- macrophage cell line.
3. Drosophila Shark tyrosine kinase signaling pathways in dorsal closureand phagocytosis: We identified the Syk family kinase, SH2 domainankyrin repeat kinase and showed that it plays a central role inembryonic dorsal closure and the recognition and engulfment of dyingneurons by glial cells. Using a two hybrid approach, we identified thereceptor activating Shark (Draper) and the upstream adaptor (Ddok) andcurrent studies in this area are focused on the elucidation of Sharksignaling pathways using biochemical and genetic approaches.
Contact
Positions are available for two postdoctoral fellows to work in any ofthese 3 areas. Green card holders or American citizens are preferred,but excellence and independence are most important. Applicants shouldsend a curriculum vitae and a description of research interests andexperience, with the names and contact information of three referencesto rizzo@aecom.yu.edu
Albert Einstein College of Medicine, Yeshiva University (http://www.aecom.yu.edu/dmb/)
Position
Postdoctoral Positions
Location
Bronx, New York
Date Posted
June 24th 2008
Date Expires
August 23th 2008
Tags
yeshiva, albert einstein, bronx, new york, postdoc, and post doc
Description
Laboratory of Dr. E. Richard Stanley
Albert Einstein College Medicine
Research in the Stanley lab (http://www.aecom.yu.edu/dmb/stanley.htm) isfocused in the three areas described below:
1. Colony Stimulating Factor-1 (CSF-1) and Interleukin-34 (IL-34) indevelopment and disease: CSF-1 is the primary growth factor regulatingtissue macrophage and osteoclast production. To study the sites of CSF-1synthesis and the actions of the cell surface and secreted isoforms ofCSF-1, we have developed CSF-1-promoter transgenic mice that exclusivelyexpress each the 3 different isoforms of CSF-1, or reporter genes, in anormal tissue-specific manner. Our targeted inactivation of the CSF-1receptor (CSF-1R) predicted the existence of a second ligand, recentlyidentified as IL-34. We are studying the biology of CSF-1 and IL-34,using transgenic and gene targeting approaches. Studies include theroles of these growth factors in hematopoiesis and gut, brain and skindevelopment and in the enhancement of tumor metastasis.
2. CSF1 receptor signal transduction: We have used proteomic approachesto identify downstream signaling molecules and analyzed the mechanism ofaction of several novel signaling intermediates, including SHP-1, DOK-1,PTP-phi, Cbl and MAYP/PSTPIP2. In current work, we are combiningproteomic and bioinformatic approaches to CSF-1R signaling and studyingCSF-1R structure/function using a novel CSF-1R /- macrophage cell line.
3. Drosophila Shark tyrosine kinase signaling pathways in dorsal closureand phagocytosis: We identified the Syk family kinase, SH2 domainankyrin repeat kinase and showed that it plays a central role inembryonic dorsal closure and the recognition and engulfment of dyingneurons by glial cells. Using a two hybrid approach, we identified thereceptor activating Shark (Draper) and the upstream adaptor (Ddok) andcurrent studies in this area are focused on the elucidation of Sharksignaling pathways using biochemical and genetic approaches.
Contact
Positions are available for two postdoctoral fellows to work in any ofthese 3 areas. Green card holders or American citizens are preferred,but excellence and independence are most important. Applicants shouldsend a curriculum vitae and a description of research interests andexperience, with the names and contact information of three referencesto rizzo@aecom.yu.edu
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