纽约西奈山医学院肝损伤氧化应激博士后岗位

Institution

Mount Sinai School of Medicine (http://www.mssm.edu/medicine/...)

Position

Postdoctoral Position

Location

1425 Madison Avenue, New York, NY 10029

Date Posted

September 3rd 2008

Date Expires

November 2nd 2008

Tags

new york, ny, and usa

Description

Role of nitrosative and oxidative stress in liver injury.

Alcohol-induced liver injury involves significant mitochondrial damage and up-regulation of inducible nitric oxide synthase leading to excessive generation of reactive oxygen species and reactive nitrogen species affecting cell survival. Understanding the molecular mechanisms of pathological nitric oxide overproduction by inducible nitric oxide synthase is of great relevance for efficient pharmacotherapy to prevent alcohol hepatotoxicity. Our laboratory has used a combination of a cutting edge proteomics technique along with a Systems Biology approach to elucidate mitochondrial proteins involved in alcoholic liver disease that could impact nitric oxide synthesis. The project will involve to dissect whether the alcohol-mediated up-regulation of argininosuccinate synthase plays a role in increased nitric oxide synthesis by inducible nitric oxide synthase in hepatocytes and to assess the biological relevance of the alcohol-mediated induction of argininosuccinate synthase for nitric oxide synthesis in vivo.

We are looking for a highly motivated postdoctoral candidate who has experience in cell biology, biochemistry and molecular biology. A solid background in alcoholic liver disease, a strong publication record, and good English are required.

Contact

To apply for this position please email a CV (one page only) and 3 reference letters to: natalia.nieto@mssm.edu