瑞典卡罗林斯卡学院神经生物学博士后岗位

Institution

Karolinska Institute

Position

A postdoctoral position is available to study salamander regeneration

Location

Stockholm

Date Posted

January 08, 2009

Date Expires

March 31, 2009

Tags

neurobiology 、skeletal muscle、regeneration、stem cell 、limb 、brain 、salamander 

Description

A postdoctoral position is available to study salamander regeneration.

Natural examples of regeneration, such as salamanders, may unravel novel strategies for cell replacement of damaged or lost tissues. We study regeneration mechanisms in an aquatic salamander, the newt, which has the widest repertoire of regenerative abilities among adult vertebrates

Our group has two main interests.

The first topic of our research is to understand how skeletal muscle contributes to new tissues during limb regeneration. We have identified a multipotent stem cell population in salamander skeletal muscle and we try to understand how these cells take part in limb regeneration. Salamander skeletal muscle may also undergo a unique dedifferentiation process during limb regeneration, and we aim to reveal the mechanisms underlying skeletal muscle dedifferentiation.

The second topic of our research is to reveal how brain regeneration can take place. Here we focus at neurogenesis/regeneration of adult dopaminergic neurons in a salamander model of Parkinsons disease. The role of GFAP expressing neural stem cells is currently in the focus of our research and we aim to understand how these are activated in the early phases of dopaminergic regeneration.

Primarily we are seeking candidates who are interested in neural regeneration and have strong background in neural biology. Candidates should have a PhD and be experienced in cell-, molecular-, and developmental biology. Training in animal research is of advantage.

Contact

E-mail: andras.simon@ki.se

Address: Dept of Cell and Molecular Biology(CMB)
Karolinska Institutet
P.O. Box 285
SE-171 77 Stockholm, Sweden