美国伊利诺伊大学神经炎性博士后岗位

Post doctoral position in neuroinflammation : Chicago, IL

Institution

University of Illinois

Position

post doctoral positions

Location

Chicago, IL

Date Posted

July 16, 2009

Date Expires

October 14, 2009 

Tags

alzheimers, amyloid, brain, inflammation

Description

A post doctoral position available beginning Fall of 2009 to study the effects of novel anti-inflammatory agents on amyloid burden, neuronal damage, and inflammation in transgenic mouse models of AD. We are interested to determine if treatment with novel thiazolidinediones, or with drugs which raise central catecholamine levels, will have beneficial effects in a novel line of PS:APP mice which normally develop plaques at 4-6 weeks. Experience with immunocytochemical methodologies, analysis of amyloid plaque burden, and of APP proteins and fragments is requisite. Studies will include analysis of changes in brain gene expression, HPLC for measures of brain catecholamine levels, behavioral testing including Morris water maze and y-maze, and in vitro studies using primary neurons and cell lines to examine regulation of protease expression and inflammatory gene expression.

The research project has strong translational and clinical potential, and possibilities exist to initiate pilot testing with colleagues in the Departments of Neurology. Broad knowledge and adequate laboratory experience in this field, good command of spoken and written English and excellent communication and team skills are required. Priority will be given to candidates with a strong expertise in amyloid biology, TgAPP mice, and inflammatory signaling pathways.

Contact

Applications, including CV, list of publications and statement of future interests should be sent to dlfeins@uic.edu. Applicants should arrange to have at least two confidential letters of reference to be sent directly by referees. Funding is available for an initial period of 1-2 years, dependent upon grant status, starting during the Fall of 2009.

来源：http://www.nature.com/naturejobs/science/jobs/103576-Post-doctoral-position-in-neuroinflammation