卡罗林斯卡研究所肿瘤分子生物学博士后岗位

Postdoctoral Fellow in Cancer Molecular Biology : Huddinge, Stockholm, Sweden

Employer:

Karolinska Institutet

Website:

http://ki.se/forskning/zaph

Location:

Huddinge, Stockholm, Sweden

Posted:

August 31, 2009

Expires:

December 15, 2009

tag(s):

sweden, stockholm, karolinska institute, molecular biology, biological sciences, cancer, postdoct

description:

Motivated and enthusiastic fellows are invited to apply for a postdoctoral position addressing the role of RNA-based mechanisms in the control of the Hedgehog signaling pathway.

In recent years there has been overwhelming evidence highlighting the significance of novel classes of RNA molecules in biological processes, including micro RNAs, antisense transcripts and splice variants. Moreover, the Hedgehog signal transduction cascade is implicated not only in developmental processes but its dysregulation has been associated with an increasing spectrum of human tumors, including medulloblastoma and pancreatic cancer. Our goals center at dissecting key molecular events, relevant to Hedgehog signaling-mediated tumorigenesis, which are mediated through novel RNA-based mechanisms.

Recent publications:

Oncogene 26, 4889-4896, 2007 (www.nature.com/onc/journal/v26/n34/abs/1210301a.html)

J. Biol.Chem. 283, 14345-14354, 2008 (www.jbc.org/cgi/content/abstract/283/21/14345)

Expertise in molecular biology techniques is required. Additionally, the capacity of independent reasoning combined with the willingness to work within a group is essential. The position is for one year but with the possibility of extension.

contact:

Please send CV and letters of recommendations to either Peter Zaphiropoulos (pezaph@ki.se) or Takashi Shimokawa (takshi@ki.se) at the Department of Biosciences and Nutrition, Karolinska Institutet, 141 57 Huddinge, Sweden.