新加坡免疫学肿瘤与炎症博士后

Postdoctoral Position In Inflammation and Cancer : Singapore

Employer:

Singapore Immunology Network

Website:

http://www.sign.a-star.edu.sg...

Location:

Singapore

Posted:

December 28, 2009

Expires:

February 26, 2010

Description:

Protumoral role of monocytes/macrophages and their use in gene therapy.Recent studies using transgenic models and tumor transcriptome profiling have provided convincing evidence for linking inflammation and cancer. One particular inflammatory cell, the monocyte/macrophage, has emerged as a central regulator of tumor onset and progression. Indeed, monocytes/macrophages represent the major proportion of the host-derived immune cells associated with most solid tumor and their recruitment/activation at these sites are largely regulated by tumor-derived signals like chemokines, cytokines and endogenous signals (e.g CCL2, VEGF, MCSF, TNF, IL-1β, angiopoietins, necrotic debris). We and others have shown that tumor-associated macrophages (TAM) in mouse tumor models or circulating monocytes from tumor bearers have phenotype which supports proangiogenic, metastatic functions thereby contributing to tumor progression.

Recent reports have suggested the existence of a novel subpopulation of monocytes/macrophages which are recruited preferentially to the tumors and carryout potent proangiogenic functions for tumor growth. Exploiting these cells, gene therapy approaches are being formulated in transgenic mice to target tumors. A collaborative project between Singapore Immunology Network (SIgN) and Hospital San Raffaele Scientific Institute (Milan,Italy) aimed at the molecular characterization of these novel monocyte subset (in human cancers and preclinical mouse models) and their potential use in gene therapy will be investigated. A 3 years postdoctoral position based in the Human Innate immunity lab in SIgN (Singapore) is immediately available (closing date March 2010) for this project. This project would involve active scientific exchange between the institutes in Singapore and Milan as well as provide strong future potentials for translational research.

We search for candidates with
——completed PhD, MD or equivalent degree
—— a good track record of international publications.
——Research experience in immunology (especially innate immunity), mice tumor models or with lentiviral or general cloning expertise will be advantageous.
Fresh PhD students who are passionate to carryout a career in cutting-edge science are also encouraged to apply.

We offer core-funding for research work, broad range of technical facilities (imaging, transcriptomics/SIgN database, mouse mutant collection, monoclonal antibodies technologies, cell sorting and flow cytometry technologies, etc) and an international scientific environment.

Enquiries for this position may be directed to:
Dr. Subhra K. Biswas
(e-mail: subhra_biswas@immunol.a-star.edu.sg )
Principal Investigator,
Human Innate Immunity lab,Singapore Immunology Network (SIgN),
Agency for Science, Technology and Research (A*STAR), Singapore.